CREB Control Cell Extracts Immunoglobulin
CREB Control Cell Extracts (cAMP Response Element Binding Protein)
Purity
Lysate
Synonyms
CREB Control Cell Extracts; CREB Control Cell Extracts (cAMP Response Element Binding Protein); CREB Control Cell Extracts immunoglobulin
Purity/Purification
Lysate
Form/Format
Supplied as a liquid in SDS Sample Buffer: 62.5mM Tris-HCl, pH 6.8 at 25 degree C, 2% w/v SDS, 10% glycerol, 50mM DTT, 0.01% w/v bromophenol blue.
Preparation and Storage
-20 degree C
Related Product Information for CREB Control Cell Extracts immunoglobulin
Transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity (1,2). Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133 (4). Phosphorylation occurs at Ser133 via p44/42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK1 (5-7). CREB appears to play an important role in learning and memory in both flies and mice. Mice lacking CREB exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively (8-10). Nonphosphorylated CREB Control Cell Extracts: Total cell extracts from SK-N-MC cells prepared without treatment serve as a negative control. Supplied in SDS Sample Buffer. Phosphorylated CREB Control Cell Extracts: Total cell extracts from SK-N-MC cells prepared with IBMX and forskolin treatment serve as a positive control. Supplied in SDS Sample Buffer.
Product Categories/Family for CREB Control Cell Extracts immunoglobulin
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Product Notes
The CREB Control Cell Extracts (Catalog #AAA652620) is an Immunoglobulin and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CREB Control Cell Extracts, Immunoglobulin" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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