Rabbit anti-Human, Rat SUV39H2 Polyclonal Antibody | anti-SUV39H2 antibody
SUV39H2, CT (Histone-lysine N-methyltransferase SUV39H2, Suppressor of Variegation 3-9 Homolog 2, Su(var)3-9 Homolog 2, Histone H3-K9 Methyltransferase 2, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, KMT1B) (FITC)
Western Blot (WB)
(Western Blot analysis in 293 and HL60 cell line lysates (35ug/lane) usingMBS626595. SUV39H2 (arrow) was detected usingMBS626595.)
Western Blot (WB)
(Western Blot analysis of lysates from A431, K562, CEM cell line and rat brain tissue lyaste (from left to right, 35ug/lane), using MBS626595 (1:1000) at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10,000 was used as the secondary antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human cancer tissue reacted withMBS626595, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS626595 for immunohistochemistry. BC = breast carcinoma; HC = hepatocarcinoma.)
NCBI and Uniprot Product Information
Uniprot Description
SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43
Chromosomal Location of Human Ortholog: 10p13
Cellular Component: nucleoplasm; nuclear heterochromatin; chromatin; chromosome, pericentric region
Molecular Function: protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K9 specific); chromatin binding
Biological Process: chromatin assembly or disassembly; chromatin remodeling; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transcription, DNA-dependent; male meiosis
Research Articles on SUV39H2
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SUV39H2 Antibody
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