Western Blot (WB)
(Western Blot analysis in human placenta tissue lysates (35ug/lane) using MBS649002. This demonstrates that MBS649002 detected the MUL1 protein (arrow).)
Rabbit anti-Human MUL1 Polyclonal Antibody | anti-MUL1 antibody
MUL1, CT (MUL1, C1orf166, GIDE, MAPL, MULAN, RNF218, Mitochondrial ubiquitin ligase activator of NFKB 1, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, Mitochondrial-anchored protein ligase, Putative
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(Western Blot analysis in human placenta tissue lysates (35ug/lane) using MBS649002. This demonstrates that MBS649002 detected the MUL1 protein (arrow).)
Western Blot (WB)
(Western Blot analysis in human placenta tissue lysates (35ug/lane) using MBS649002. This demonstrates that MBS649002 detected the MUL1 protein (arrow).)
NCBI and Uniprot Product Information
Uniprot Description
Function: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Ref.1 Ref.7 Ref.8 Ref.9
Pathway: Protein modification; protein ubiquitination.Protein modification; protein sumoylation.
Subunit structure: Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with and sumoylates DNM1L. Ref.1 Ref.9
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. Ref.1 Ref.7 Ref.8
Tissue specificity: Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. Ref.1 Ref.8
Domain: The zinc finger domain is required for E3 ligase activity.
Sequence similarities: Contains 1 RING-type zinc finger.
Research Articles on MUL1
Similar Products
Product Notes
The MUL1 mul1 (Catalog #AAA649002) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MUL1, CT (MUL1, C1orf166, GIDE, MAPL, MULAN, RNF218, Mitochondrial ubiquitin ligase activator of NFKB 1, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, Growth inhibition and death E3 ligase, Mitochondrial-anchored protein ligase, Putative reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MUL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the MUL1 mul1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MUL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
