Western Blot (WB)
(FLJ11506 polyclonal antibody. Western Blot analysis of FLJ11506 expression in human colon.)
Mouse anti-Human AAGAB Polyclonal Antibody | anti-AAGAB antibody
AAGAB (FLJ11506, Alpha- And Gamma-adaptin-binding Protein P34, DKFZp667D2317, DKFZp686G08119)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(FLJ11506 polyclonal antibody. Western Blot analysis of FLJ11506 expression in human colon.)
Western Blot (WB)
(FLJ11506 polyclonal antibody. Western Blot analysis of FLJ11506 expression in human colon.)
Western Blot (WB)
(Western Blot analysis of FLJ11506 expression in transfected 293T cell line by FLJ11506 polyclonal antibody. Lane 1: FLJ11506 transfected lysate (34.65kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of FLJ11506 expression in transfected 293T cell line by FLJ11506 polyclonal antibody. Lane 1: FLJ11506 transfected lysate (34.65kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Description
Function: May be involved in endocytic recycling of growth factor receptors such as EGFR. Ref.11
Subunit structure: Associated with AP-1 and AP-2 complexes. Ref.11
Subcellular location: Cytoplasm › cytosol Ref.10 Ref.11.
Tissue specificity: Widely expressed, including in skin and keratinocytes, with highest levels in adrenal gland, rectum and thymus. Ref.10 Ref.11
Involvement in disease: Keratoderma, palmoplantar, punctate 1A (PPKP1A) [MIM:148600]: An autosomal dominant dermatological disorder characterized by multiple hyperkeratotic, centrally indented, papules that develop in early adolescence, or later, and are irregularly distributed on the palms and soles (other palmoplantar keratoses have mostly diffuse hyperkeratinization). In mechanically irritated areas, confluent plaques can be found. Interfamilial and intrafamilial severity shows broad variation. In some cases, PPKP1 is associated with the development of early- and late-onset malignancies, including squamous cell carcinoma.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11
Research Articles on AAGAB
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Product Notes
The AAGAB aagab (Catalog #AAA645565) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The AAGAB (FLJ11506, Alpha- And Gamma-adaptin-binding Protein P34, DKFZp667D2317, DKFZp686G08119) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AAGAB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the AAGAB aagab for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAAGVPCALV TSCSSVFSGD QLVQHILGTE DLIVEVTSND AVRFYPWTID NKYYSADINL CVVPNKFLVT AEIAESVQAF VVYFDSTQKS GLDSVSSWLP LAKAWLPEVM ILVCDRVSED GINRQKAQEW CIKHGFELVE LSPEELPEED DDFPESTGVK RIVQALNANV WSNVVMKNDR NQGFSLLNSL TGTNHSIGSA DPCHPEQPHL PAADSTESLS DHRGGASNTT DAQVDSIVDP MLDLDIQELA SLTTGGGDVE NFERLFSKLK EMKDKAATLP HEQRKVHAEK VAKAFWMAIG GDRDEIEGLS SDEEH. It is sometimes possible for the material contained within the vial of "AAGAB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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