Rabbit anti-Human MAGEH1 Polyclonal Antibody | anti-MAGEH1 antibody

MAGEH1 (Melanoma-associated Antigen H1, MAGE-H1 Antigen, Restin, Apoptosis-related Protein 1, APR-1, APR1) (AP)

Cat. Num. AAA6384642

• Gene Names: MAGEH1; APR1; APR-1; MAGEH
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MAGEH1; Polyclonal Antibody; MAGEH1 (Melanoma-associated Antigen H1; MAGE-H1 Antigen; Restin; Apoptosis-related Protein 1; APR-1; APR1) (AP); anti-MAGEH1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MAGEH1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-MAGEH1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human MAGEH1, aa1-219 (NP_054780.2).
• Immunogen Sequence: MPRGRKSRRRRNARAAEENRNNRKIQASEASETPMAASVVASTPEDDLSGPEEDPSTPEEASTTPEEASSTAQAQKPSVPRSNFQGTKKSLLMSILALIFIMGNSAKEALVWKVLGKLGMQPGRQHSIFGDPKKIVTEEFVRRGYLIYKPVPRSSPVEYEFFWGPRAHVESSKLKVMHFVARVRNRCSKDWPCNYDWDSDDDAEVEAILNSGARGYSAP
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MAGEH1 expression in transfected 293T cell line by MAGEH1 polyclonal antibody. Lane 1: MAGEH1 transfected lysate (24.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-MAGEH1 antibody

Melanoma-associated antigen (MAGE) are completely silent in normal tissues, with the exception of male germ cells, and, for some of them, placenta. These antigens ought to be strictly tumor specific, expressed in tumor cells of various histological types. Because of their specific expression on tumor cells, these antigens are of particular interest for antitumor immunotherapy. Genes of the MAGE family direct the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes. Though the function of MAGEH1 is not fully elucidated, it may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Product Categories/Family for anti-MAGEH1 antibody

Antibodies; Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 15042941
• NCBI GeneID: 28986
• NCBI Accession #: NP_054780.2
• NCBI GenBank Nucleotide #: NM_014061.3
• UniProt Accession #: Q9H213; Q5JRJ3; Q9Y5M2; B2R8V9
• Molecular Weight: 24,441 Da
• NCBI Official Full Name: melanoma-associated antigen H1
• NCBI Official Synonym Full Names: melanoma antigen family H, 1
• NCBI Official Symbol: MAGEH1
• NCBI Official Synonym Symbols: APR1; APR-1; MAGEH
• NCBI Protein Information: melanoma-associated antigen H1; restin; apoptosis-related protein 1
• UniProt Protein Name: Melanoma-associated antigen H1
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEH1
• UniProt Synonym Gene Names: APR1; APR-1
• UniProt Entry Name: MAGH1_HUMAN

NCBI Description

This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]

Uniprot Description

MAGE-H1:

Chromosomal Location of Human Ortholog: Xp11.21

Cellular Component: cytoplasm

Biological Process: apoptosis