Collapsin Response Mediator Protein 1 Recombinant Protein
Collapsin Response Mediator Protein 1, Recombinant, Human (CRMP1, Dihydropyrimidinase-like 1, DPYSL1, DRP1, ULIP3, CRAM)
Purity
PurifiedOn SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 39kD
Synonyms
Collapsin Response Mediator Protein 1; Recombinant; Human (CRMP1; Dihydropyrimidinase-like 1; DPYSL1; DRP1; ULIP3; CRAM); Collapsin Response Mediator Protein 1 recombinant protein
Host
E Coli
Purity/Purification
Purified
On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 39kD
On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 39kD
Form/Format
Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol. Composed of a.a. 448-568 plus GST tag.
Application Notes
Suitable for use in ELISA, Inhibition Assays, Western Blotting.
Preparation and Storage
-20 degree C
Stability: Store vial at -20-80 degree C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.
Stability: Store vial at -20-80 degree C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.
Related Product Information for Collapsin Response Mediator Protein 1 recombinant protein
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The X-ray crystal structure of murine CRMP1 was determined at 2.1 resolution and demonstrates that CRMP1 is a bilobed 'lung-shaped' protein forming a tetrameric assembly.
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydropyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydropyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
Product Categories/Family for Collapsin Response Mediator Protein 1 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
39kD
NCBI Official Full Name
collapsin response mediator protein 1
Uniprot Description
CRMP-1: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Cell development/differentiation; Hydrolase
Chromosomal Location of Human Ortholog: 4p16.1
Cellular Component: cell soma; dendrite; cytoplasm; microtubule organizing center; spindle; cytosol
Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; protein binding
Biological Process: nervous system development; axon guidance; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine base catabolic process
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Product Notes
The Collapsin Response Mediator Protein 1 (Catalog #AAA637865) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. Suitable for use in ELISA, Inhibition Assays, Western Blotting. Researchers should empirically determine the suitability of the Collapsin Response Mediator Protein 1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Collapsin Response Mediator Protein 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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