Rabbit anti-Human TSPAN7 Polyclonal Antibody | anti-TSPAN7 antibody

TSPAN7, ID (TSPAN7, A15, DXS1692E, MXS1, TM4SF2, Tetraspanin-7, Cell surface glycoprotein A15, Membrane component chromosome X surface marker 1, T-cell acute lymphoblastic leukemia-associated antigen 1, Transmembrane 4 superfamily member 2, CD231) (AP)

Cat. Num. AAA6359639

• Gene Names: TSPAN7; A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; TALLA-1; TM4SF2b; DXS1692E
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TSPAN7; Polyclonal Antibody; ID (TSPAN7; A15; DXS1692E; MXS1; TM4SF2; Tetraspanin-7; Cell surface glycoprotein A15; Membrane component chromosome X surface marker 1; T-cell acute lymphoblastic leukemia-associated antigen 1; Transmembrane 4 superfamily member 2; CD231) (AP); CD231; anti-TSPAN7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-TSPAN7 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TSPAN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 100-140 from the Central region of human TSPAN7.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of TSPAN7 Antibody (Center) in CEM cell line lysates (35ug/lane). TSPAN7 (arrow) was detected using the purified Pab.)

Flow Cytometry (FC/FACS)

(TSPAN7 Antibody (Center) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-TSPAN7 antibody

TSPAN7 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.

Product Categories/Family for anti-TSPAN7 antibody

Antibodies; Tetraspanin

References

Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009). Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009). Noor, A., et al. Psychiatr. Genet. 19(3):154-155(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 21265104
• NCBI GeneID: 7102
• NCBI Accession #: NP_004606.2
• NCBI GenBank Nucleotide #: NM_004615.3
• UniProt Accession #: P41732; Q8WVG5; Q9UEY9; B2R5W7; D3DWB1
• Molecular Weight: 27,574 Da
• NCBI Official Full Name: tetraspanin-7
• NCBI Official Synonym Full Names: tetraspanin 7
• NCBI Official Symbol: TSPAN7
• NCBI Official Synonym Symbols: A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; TALLA-1; TM4SF2b; DXS1692E
• NCBI Protein Information: tetraspanin-7; tspan-7; CD231 antigen; tetraspanin protein; transmembrane protein A15; cell surface glycoprotein A15; transmembrane 4 superfamily 2b; transmembrane 4 superfamily member 2; membrane component chromosome X surface marker 1; membrane componen
• UniProt Protein Name: Tetraspanin-7
• UniProt Gene Name: TSPAN7
• UniProt Synonym Gene Names: A15; DXS1692E; MXS1; TM4SF2; Tspan-7; TALLA-1
• UniProt Entry Name: TSN7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008]

Uniprot Description

TSPAN7: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Defects in TSPAN7 are the cause of mental retardation X- linked type 58 (MRX58). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: integral to plasma membrane

Biological Process: viral reproduction

Disease: Mental Retardation, X-linked 58