Related Product Information for anti-TEAD2 antibody
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Product Categories/Family for anti-TEAD2 antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Tian, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7293-7298(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Zhang, H., et al. J. Biol. Chem. 284(20):13355-13362(2009). Zhao, B., et al. Genes Dev. 22(14):1962-1971(2008).
Uniprot Description
TEAD2: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; transcription factor activity
Biological Process: paraxial mesoderm development; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; neural tube closure; lateral mesoderm development; gene expression; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis; notochord development
Product Notes
The TEAD2 tead2 (Catalog #
AAA6354679) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TEAD2, ID (TEAD2, TEF4, Transcriptional enhancer factor TEF-4, TEA domain family member 2) (APC) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TEAD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the TEAD2 tead2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"TEAD2, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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