Testing Data
Rabbit anti-Human, Mouse TEAD2 Polyclonal Antibody | anti-TEAD2 antibody
Anti-TEAD2 Antibody
Supplied in 0.42%, Potassium phosphate, 0.87% Sodium chloride; pH 7.3, 30% glycerol, and 0.01% sodium azide.
IHC: 1:50- 1:200
IF/IC: 1:50- 1:100
ChIP: 1:100- 1:500
Note: This information is only intented as a guide. The optimal dilutions must be determined by the user.
For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Testing Data
Testing Data
Transcription factor which plays a key role in the Hippo signaling pathway; a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2; in complex with its regulatory protein SAV1; phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1; which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ; thereby regulating cell proliferation; migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
NCBI and Uniprot Product Information
Uniprot Description
TEAD2: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytosol; intracellular membrane-bound organelle; nucleoplasm
Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: embryonic organ development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; transcription initiation from RNA polymerase II promoter
Research Articles on TEAD2
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Product Notes
The TEAD2 tead2 (Catalog #AAA846045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TEAD2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TEAD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB); Immunohistochemistry (IHC); Immunofluorescence (IF); Immunocytochemistry (ICC). WB: 1:500- 1:2000 IHC: 1:50- 1:200 IF/IC: 1:50- 1:100 ChIP: 1:100- 1:500 Note: This information is only intented as a guide. The optimal dilutions must be determined by the user. Researchers should empirically determine the suitability of the TEAD2 tead2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TEAD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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