Rabbit anti-Mouse Tbk1 Polyclonal Antibody | anti-Tbk1 antibody

Tbk1, NT (Tbk1, Serine/threonine-protein kinase TBK1, T2K, TANK-binding kinase 1) (PE)

Cat. Num. AAA6354083

• Gene Names: Tbk1; AI462036; AW048562; 1200008B05Rik
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: Tbk1; Polyclonal Antibody; NT (Tbk1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1) (PE); TANK-binding kinase 1; anti-Tbk1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Tbk1.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-Tbk1 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 8-35 in the N-terminal region of mouse Tbk1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse cerebellum tissue lysates (35ug/lane) usingMBS6006244. This demonstrates that MBS6006244 detected the Tbk1 protein (arrow).)

Related Product Information for anti-Tbk1 antibody

Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.

Product Categories/Family for anti-Tbk1 antibody

Antibodies; Protein Kinases

References

1. Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010). 2. Watanabe, T., et al. J. Clin. Invest. 120(5):1645-1662(2010). 3. Gabhann, J.N., et al. J. Immunol. 184(5):2314-2320(2010). 4. Munoz, M.C., et al. J. Endocrinol. 201(2):185-197(2009). 5. Miyahira, A.K., et al. J. Immunol. 182(4):2248-2257(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 251823839
• NCBI GeneID: 56480
• NCBI Accession #: NP_062760.3
• NCBI GenBank Nucleotide #: NM_019786.4
• UniProt Accession #: Q9WUN2; Q9CT90; Q9DC03
• Molecular Weight: 83,425 Da
• NCBI Official Full Name: serine/threonine-protein kinase TBK1
• NCBI Official Synonym Full Names: TANK-binding kinase 1
• NCBI Official Symbol: Tbk1
• NCBI Official Synonym Symbols: AI462036; AW048562; 1200008B05Rik
• NCBI Protein Information: serine/threonine-protein kinase TBK1; T2K; serine/threonine protein kinase TBK1
• UniProt Protein Name: Serine/threonine-protein kinase TBK1
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: Tbk1
• UniProt Entry Name: TBK1_MOUSE