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Western Blot (WB) (Mouse Tbk1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the Tbk1 antibody detected the Tbk1 protein (arrow).)

Rabbit anti-Mouse Tbk1 Polyclonal Antibody | anti-Tbk1 antibody

Mouse Tbk1 Antibody (N-term)

Gene Names
Tbk1; AI462036; AW048562; 1200008B05Rik
Reactivity
Mouse
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Tbk1; Polyclonal Antibody; Mouse Tbk1 Antibody (N-term); Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; anti-Tbk1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Mouse Tbk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of mouse Tbk1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
8-35
Sequence Length
729
Applicable Applications for anti-Tbk1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Mouse Tbk1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the Tbk1 antibody detected the Tbk1 protein (arrow).)

Western Blot (WB) (Mouse Tbk1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the Tbk1 antibody detected the Tbk1 protein (arrow).)
Related Product Information for anti-Tbk1 antibody
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.
Product Categories/Family for anti-Tbk1 antibody
References
Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010)
Watanabe, T., et al. J. Clin. Invest. 120(5):1645-1662(2010)
Gabhann, J.N., et al. J. Immunol. 184(5):2314-2320(2010)
Munoz, M.C., et al. J. Endocrinol. 201(2):185-197(2009)
Miyahira, A.K., et al. J. Immunol. 182(4):2248-2257(2009)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
83425
NCBI Official Full Name
serine/threonine-protein kinase TBK1
NCBI Official Synonym Full Names
TANK-binding kinase 1
NCBI Official Symbol
Tbk1
NCBI Official Synonym Symbols
AI462036; AW048562; 1200008B05Rik
NCBI Protein Information
serine/threonine-protein kinase TBK1
UniProt Protein Name
Serine/threonine-protein kinase TBK1
UniProt Gene Name
Tbk1
UniProt Entry Name
TBK1_MOUSE

Uniprot Description

TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; IKK family

Cellular Component: cytoplasm

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; nucleic acid binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phosphoprotein binding; kinase activity; ATP binding; protein kinase activity

Biological Process: defense response to Gram-positive bacterium; immune system process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; defense response to virus; phosphorylation; activation of innate immune response; positive regulation of interferon-alpha production

Research Articles on Tbk1

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Product Notes

The Tbk1 tbk1 (Catalog #AAA9203960) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 8-35. The Mouse Tbk1 Antibody (N-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Tbk1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Tbk1 tbk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tbk1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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