Related Product Information for anti-SYTL4 antibody
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.
Product Categories/Family for anti-SYTL4 antibody
References
Plaisance, V., et al. J. Biol. Chem. 281(37):26932-26942(2006). Ciufo, L.F., et al. Mol. Biol. Cell 16(2):470-482(2005). Fukuda, M. J. Biol. Chem. 278(17):15390-15396(2003). Fukuda, M., et al. J. Biol. Chem. 277(42):39673-39678(2002). Torii, S., et al. Mol. Cell. Biol. 22(15):5518-5526(2002).
NCBI Description
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Uniprot Description
SYTL4: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: Xq21.33
Cellular Component: nucleoplasm; centrosome; synaptic vesicle; extrinsic to membrane; cytoplasm; plasma membrane; endosome; secretory granule
Molecular Function: zinc ion binding; transporter activity; neurexin binding; phospholipid binding; Rab GTPase binding
Biological Process: intracellular protein transport; exocytosis; positive regulation of protein secretion; negative regulation of insulin secretion; positive regulation of exocytosis
Product Notes
The SYTL4 sytl4 (Catalog #
AAA6353112) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SYTL4, NT (SYTL4, Synaptotagmin-like protein 4, Exophilin-2, Granuphilin) (MaxLight 550) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SYTL4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SYTL4 sytl4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"SYTL4, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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aspect of this datasheet at
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of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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