Testing Data
(PHA-treated T cells were stained with anti-4-1BB, filled histogram) or control antibody, open histogram) followed by APC-conjugated anti-goat IgG.)
CD137 Protein
CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor)
Reactivity
Human
Applications
ELISA, Western Blot, Immunocytochemistry, Flow Cytometry, Functional Assay
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
CD137; Polyclonal Protein; CD137 (4-1BB; TNFRSF9; 4-1BB ligand receptor; CD137 antigen; CDw137; ILA; MGC2172; T-cell antigen 4-1BB homolog; T-cell antigen ILA; Tumor necrosis factor receptor superfamily member 9 precursor); CD137 protein
Host
Goat
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes the extracellular domain of human CD137. In ELISA, <0.1% crossreactivity with recombinant mouse CD137, recombinant human NGF R, TNF RI and TNF RII is observed. In Western Blot, shows <1% crossreactivity with recombinant human NGF R, sTNF RI, sTNF RII and recombinant mouse sTNF RI and sTNF RII.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
Applicable Applications for CD137 protein
ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Immunogen
Recombinant corresponding to the extracellular domain of human CD137 expressed in NSO cells.
Product Type
Pab
Preparation and Storage
-20 degree C
Testing Data
(PHA-treated T cells were stained with anti-4-1BB, filled histogram) or control antibody, open histogram) followed by APC-conjugated anti-goat IgG.)
Testing Data
(PHA-treated T cells were stained with anti-4-1BB, filled histogram) or control antibody, open histogram) followed by APC-conjugated anti-goat IgG.)
Related Product Information for CD137 protein
CD137 is an inducible T cell surface protein belonging to the TNF receptor superfamily. The 255aa human CD137 is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30kD glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% aa identity. CD137 is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, CD137L, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Cross-linking of CD137 by CD137L or by agonistic antibodies transmits a potent co-stimulatory signal that enhances the effect of other activating signals such as PHA or anti-CD3 antibodies. CD137 signals through the TFAF2-NIK pathway resulting in activation of NF-kappaB and ultimately promoting proliferation and survival of T cells.
Product Categories/Family for CD137 protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI Official Full Name
CD137
Similar Products
Product Notes
The CD137 (Catalog #AAA635261) is a Protein produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor superfamily member 9 precursor) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD137 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD137 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD137, Polyclonal Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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