Mouse anti-Human GCET2 Monoclonal Antibody | anti-GCET2 antibody

GCET2 (Germinal Center B-cell-expressed Transcript 2 Protein, Germinal Center-associated Lymphoma Protein, hGAL, GAL)

Cat. Num. AAA632967

• Gene Names: GCET2; HGAL; GCAT2; MGC40441
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified; Purified
• Synonyms: GCET2; Monoclonal Antibody; GCET2 (Germinal Center B-cell-expressed Transcript 2 Protein; Germinal Center-associated Lymphoma Protein; hGAL; GAL); Anti -GCET2 (Germinal Center B-cell-expressed Transcript 2 Protein; anti-GCET2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 1E9
• Specificity: Recognizes human GCET2.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-GCET2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1-5ug/ml using recombinant protein.; Western Blot (Cell lysate): 1-5ug/ml. Specific band identified at ~21kD using Jurkat lysate.; Western Blot (Recombinant lysate protein): 1-5ug/ml. Specific band of ~45kD identified using immuogen protein lysate.
• Immunogen: Full length recombinant protein corresponding to aa1-179 from human GCET2 with GST tag (AAH30506). MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GCET2 antibody

GCET2, commonly known as germinal center B cell expressed transcript 2 protein, is a 178aa protein expressed in diffuse large B cell lymphoma (DLBCL) and several germinal center (GC) like lymphoma cell lines (at protein level). It is highly expressed in normal GC lymphocytes and GC derived malignancies, as well as being present in the thymus and spleen. In B cells expression of the HGAL gene is specifically induced by interleukin 4.

Product Categories/Family for anti-GCET2 antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 298231245
• NCBI GeneID: 257144
• NCBI Accession #: NP_001177189.1
• NCBI GenBank Nucleotide #: NM_001190260.1
• UniProt Accession #: Q8N6F7
• Molecular Weight: 21,005 Da
• NCBI Official Full Name: germinal center B-cell-expressed transcript 2 protein isoform 4
• NCBI Official Synonym Full Names: germinal center expressed transcript 2
• NCBI Official Symbol: GCET2
• NCBI Official Synonym Symbols: HGAL; GCAT2; MGC40441
• NCBI Protein Information: germinal center B-cell-expressed transcript 2 protein; OTTHUMP00000214427; OTTHUMP00000214474; OTTHUMP00000214477; OTTHUMP00000214479; OTTHUMP00000214480; germinal center-associated lymphoma protein
• UniProt Protein Name: Germinal center B-cell-expressed transcript 2 protein
• UniProt Gene Name: GCET2
• UniProt Synonym Gene Names: GAL
• UniProt Entry Name: GCET2_HUMAN

NCBI Description

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Uniprot Description

GCET2: a protein expressed in normal germinal center B cells, immature B and T cells. Induced by IL4. Its expression strongly predicts survival in diffuse large B-cell lymphoma.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein binding; actin binding; protein kinase binding; myosin II binding

Biological Process: regulation of B cell receptor signaling pathway