GCET2 recombinant protein

GCET2, 1-178aa, Human, His tag, E Coli

Cat. Num. AAA204823

• Gene Names: GCSAM; HGAL; GCAT2; GCET2
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: GCET2; 1-178aa; Human; His tag; E Coli; Germinal center B-cell-expressed transcript 2 protein; GCAT2; HGAL; GCET2 recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 1mM DTT
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGNSLLR ENRRQQNTQE MPWNVRMQSP KQRTSRCWDH HIAEGCFCLP WKKILIFEKR QDSQNENERM SSTPIQDNVD QTYSEELCYT LINHRVLCTR PSGNSAEEYY ENVPCKAERP RESLGGTETE YSLLHMPSTD PRHARSPEDE YELLMPHRIS SHFLQQPRPL MAPSETQFSH L
• Sequence Length: 178

• Applicable Applications for GCET2 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for GCET2 recombinant protein

GCET2 is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Recombinant human GCET2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for GCET2 recombinant protein

Cancer

References

Cubedo E, Maurin M, et al. (2011). FEBS J. 278 (17):3065-75.; Temmins C, Zhao S, et al. (2011). Appl Immunohistochem Mol Morphol. 19 (3):266-72.;

NCBI and Uniprot Product Information

• NCBI GI #: 22749537
• NCBI GeneID: 257144
• NCBI Accession #: NP_689998
• NCBI GenBank Nucleotide #: NM_152785.4
• UniProt Accession #: Q8N6F7; C9JD17; C9JUG6
• Molecular Weight: 23 kDa (201aa) confirmed by MALDI-TOF
• NCBI Official Full Name: germinal center-associated signaling and motility protein isoform 1
• NCBI Official Synonym Full Names: germinal center associated signaling and motility
• NCBI Official Symbol: GCSAM
• NCBI Official Synonym Symbols: HGAL; GCAT2; GCET2
• NCBI Protein Information: germinal center-associated signaling and motility protein
• UniProt Protein Name: Germinal center-associated signaling and motility protein
• UniProt Gene Name: GCSAM
• UniProt Synonym Gene Names: GAL; GCET2; hGAL

NCBI Description

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.