Mouse anti-Human, Mouse Fibrinogen, Citrullinated Monoclonal Antibody
Fibrinogen, Citrullinated (FGA, FGB, FGG, Fibrinogen A alpha Polypeptide Chain, Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405)
Reactivity
Human, Mouse
Applications
ELISA
Purity
Affinity PurifiedPurified by Protein A affinity chromatography.
Synonyms
Fibrinogen; Citrullinated; Monoclonal Antibody; Citrullinated (FGA; FGB; FGG; Fibrinogen A alpha Polypeptide Chain; Fibrinogen alpha Chain; Fibrinogen beta Chain; Fibrinogen gamma Chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405); Anti -Fibrinogen; anti-Fibrinogen; Citrullinated antibody
Host
Mouse
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
20B2
Specificity
Recognizes mouse deiminated fibrinogen. Species Crossreactivity: human
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a lyophilized powder from 10mM ammonium bicarbonate, 1% BSA. Reconstitute with 200ul sterile PBS or Tris-HCl, pH 7-8.
Applicable Applications for anti-Fibrinogen, Citrullinated antibody
ELISA (EL/EIA)
Application Notes
Suitable for use in ELISA.
Immunogen
Deiminated mouse fibrinogen peptide.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS or Tris-HCl. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Fibrinogen, Citrullinated antibody
Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deïminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis. Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get deiminated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the identification of rheumatoid arthritis.
Product Categories/Family for anti-Fibrinogen, Citrullinated antibody
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Product Notes
The Fibrinogen, Citrullinated (Catalog #AAA632440) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Fibrinogen, Citrullinated (FGA, FGB, FGG, Fibrinogen An alpha Polypeptide Chain, Fibrinogen alpha Chain, Fibrinogen beta Chain, Fibrinogen gamma Chain, MGC104327, MGC119422, MGC119423, MGC119425, MGC120405) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Fibrinogen, Citrullinated can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Researchers should empirically determine the suitability of the Fibrinogen, Citrullinated for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fibrinogen, Citrullinated, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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