Rabbit anti-Rat ATP Binding Cassette subfamily G, Member 5, Polyclonal Antibody | anti-ABCG1 antibody

Anti-ATP Binding Cassette subfamily G, Member 5, (ABCG5, Sterolin-1)

Cat. Num. AAA630883

• Gene Names: ABCG1; ABC8; WHITE1; MGC34313
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified
• Synonyms: ATP Binding Cassette subfamily G; Member 5; ; Polyclonal Antibody; Anti-ATP Binding Cassette subfamily G; (ABCG5; Sterolin-1); ABCG5; Sterolin-1; anti-ABCG1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat ABCG5. Species sequence homology: human.
• Purity/Purification: Affinity Purified
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-ABCG1 antibody: ELISA; Western Blot
• Application Notes: Recommended Dilutions: Western Blot: 1-10ug/ml (ECL); ELISA: 0.5-1ug/ml
• Immunogen: Synthetic peptide corresponding to 14aa of human ABCG5 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.; Shipping Temperature: Blue Ice

Related Product Information for anti-ABCG1 antibody

The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts for numerous proteins involved in trafficking of biological molecules across membranes, host-defense mechanism to xenobiotics. The first known members were Pglycoprotein (P-gp) and multidrug resistant protein (MRP), cause multidrug resistance when transfected into drugsensitive cells. In addition, increasing numbers of ABC proteins have recently been identified. The human ABCG1 (ABC, subfamily G, member 1) gene encodes a member of ABC superfamily that mediates the ATP-dependent translocation of variety of amphiphilic and lipophilic molecules. ABCG proteins were able to transport substances across cellular membranes and against concentration gradient they require an input of energy, which requires the hydrolysis of ATP, directly or indirectly.

ABCG5 gene product a 651aa residue in human, and 652aa each in rat and mouse, plays an important role in the selective transport of cholesterol in and out of the enterocytes and in the selective sterol excretion by liver into bile. Strongly expressed in liver, intestine and colon. Defects in ABCG5 results increased intestinal absorption of sterols and decreased biliary excretion of dietary sterols into bile; the condition is referred as sitosterolemia.

Product Categories/Family for anti-ABCG1 antibody

Abs to Transporters

NCBI and Uniprot Product Information

• NCBI GI #: 46592964
• NCBI GeneID: 9619
• NCBI Accession #: NP_997510.1
• NCBI GenBank Nucleotide #: NM_207627.1
• UniProt Accession #: O43576; P45844
• Molecular Weight: 26,479 Da
• NCBI Official Full Name: ATP-binding cassette sub-family G member 1 isoform 5
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family G (WHITE), member 1
• NCBI Official Symbol: ABCG1
• NCBI Official Synonym Symbols: ABC8; WHITE1; MGC34313
• NCBI Protein Information: ATP-binding cassette sub-family G member 1; ABC transporter 8; OTTHUMP00000109322; OTTHUMP00000109323; OTTHUMP00000109324; OTTHUMP00000109325; OTTHUMP00000109326; OTTHUMP00000109327; homolog of Drosophila white; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; white protein homolog (ATP-binding cassette transporter 8)
• UniProt Protein Name: White protein homolog
• Protein Family: ABC transporter G family
• UniProt Gene Name: white
• UniProt Entry Name: O43576_HUMAN