Rabbit anti-Human GDI2 Polyclonal Antibody | anti-GDI2 antibody

GDI2, ID (GDI2, RABGDIB, Rab GDP dissociation inhibitor beta, Guanosine diphosphate dissociation inhibitor 2) (MaxLight 490)

Cat. Num. AAA6301858

• Gene Names: GDI2; RABGDIB; HEL-S-46e
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GDI2; Polyclonal Antibody; ID (GDI2; RABGDIB; Rab GDP dissociation inhibitor beta; Guanosine diphosphate dissociation inhibitor 2) (MaxLight 490); Guanosine diphosphate dissociation inhibitor 2; anti-GDI2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-GDI2 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: GDI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human GDI2.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-GDI2 antibody

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Product Categories/Family for anti-GDI2 antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

References

Rikova, K., et al. Cell 131(6):1190-1203(2007). Sun, Z.L., et al. Biochim. Biophys. Acta 1774(6):764-771(2007). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006). Shin, B.K., et al. J. Biol. Chem. 278(9):7607-7616(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 6598323
• NCBI GeneID: 2665
• NCBI Accession #: NP_001485.2; NP_001108628.1
• NCBI GenBank Nucleotide #: NM_001494.3
• UniProt Accession #: P50395; O43928; Q5SX88; Q9UQM6
• Molecular Weight: 45,619 Da
• NCBI Official Full Name: rab GDP dissociation inhibitor beta isoform 1
• NCBI Official Synonym Full Names: GDP dissociation inhibitor 2
• NCBI Official Symbol: GDI2
• NCBI Official Synonym Symbols: RABGDIB; HEL-S-46e
• NCBI Protein Information: rab GDP dissociation inhibitor beta; GDI-2; rab GDI beta; rab GDP-dissociation inhibitor, beta; guanosine diphosphate dissociation inhibitor 2; epididymis secretory sperm binding protein Li 46e
• UniProt Protein Name: Rab GDP dissociation inhibitor beta
• Protein Family: Guanosine nucleotide diphosphate dissociation inhibitor
• UniProt Gene Name: GDI2
• UniProt Synonym Gene Names: RABGDIB; Rab GDI beta; GDI-2

NCBI Description

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.