Mouse anti-Human INTS7 Polyclonal Antibody | anti-INTS7 antibody

INTS7 (Integrator Complex Subunit 7, Int7, C1orf73)

Cat. Num. AAA644486

• Gene Names: INTS7; INT7; C1orf73
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: INTS7; Polyclonal Antibody; INTS7 (Integrator Complex Subunit 7; Int7; C1orf73); Anti -INTS7 (Integrator Complex Subunit 7; anti-INTS7 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human INTS7.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRSATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYTRF

• Applicable Applications for anti-INTS7 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Suitable for use in Western Blot and Immunofluorescence.; Dilution: Immunofluorescence: 10ug/ml
• Immunogen: Full length human INTS7, aa1-962 (NP_056249.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of INTS7 expression in transfected 293T cell line by INTS7 polyclonal antibody. Lane 1: C1orf73 transfected lysate (105.82kD). Lane 2: Non-transfected lysate.)

Immunofluorescence (IF)

(Immunofluorescence of purified antibody to C1orf73 on HeLa cell. [antibody concentration 10ug/ml])

Related Product Information for anti-INTS7 antibody

INTS7 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit and mediates 3-prime end processing of small nuclear RNAs U1 and U2.

Product Categories/Family for anti-INTS7 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 315283203
• NCBI GeneID: 25896
• NCBI Accession #: NP_001186741.1
• NCBI GenBank Nucleotide #: NM_001199812.1
• UniProt Accession #: Q9NVH2; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVU5; Q9UFC6; Q9UFM3; B4DLZ6; B7WNP6; B7WPB6
• Molecular Weight: 106,834 Da
• NCBI Official Full Name: integrator complex subunit 7 isoform 3
• NCBI Official Synonym Full Names: integrator complex subunit 7
• NCBI Official Symbol: INTS7
• NCBI Official Synonym Symbols: INT7; C1orf73
• NCBI Protein Information: integrator complex subunit 7
• UniProt Protein Name: Integrator complex subunit 7
• Protein Family: Integrator complex
• UniProt Gene Name: INTS7
• UniProt Synonym Gene Names: C1orf73; Int7
• UniProt Entry Name: INT7_HUMAN

NCBI Description

This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

INTS7: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. Belongs to the Integrator subunit 7 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: chromosome; integrator complex

Molecular Function: protein binding

Biological Process: DNA damage checkpoint; snRNA processing