Biglycan / PG-S1 / BGN Recombinant Protein | BGN recombinant protein

Recombinant Mouse Biglycan / PG-S1 / BGN Protein (Fc tag)

Cat. Num. AAA2546799

• Gene Names: BGN; PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
• Purity: > 85 % as determined by SDS-PAGE
• Synonyms: Biglycan / PG-S1 / BGN; Recombinant Mouse Biglycan / PG-S1 / BGN Protein (Fc tag); BGN; BGN recombinant protein

• Host: Human Cells
• Purity/Purification: > 85 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 368

• Application Notes: The recombinant mouse BGN /Fc is a disulfide-linked homodimer. The reduced monomer comprises 591 amino acids and has a predicted molecular mass of 66.5 KDa. The apparent molecular mass of the protein is approximately 67 KDa in SDS-PAGE under reducing conditions due to glycosylation.
• Predicted N Terminal: Glu 20
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for BGN recombinant protein

Background: Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.

Description: A DNA sequence encoding the mouse BGN (Met1-Lys369) was expressed with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 4502403
• NCBI GeneID: 633
• NCBI Accession #: NP_001702.1
• NCBI GenBank Nucleotide #: NM_001711.5
• UniProt Accession #: P21810; P13247; D3DWU3
• Molecular Weight: 41,654 Da
• NCBI Official Full Name: biglycan preproprotein
• NCBI Official Synonym Full Names: biglycan
• NCBI Official Symbol: BGN
• NCBI Official Synonym Symbols: PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
• NCBI Protein Information: biglycan
• UniProt Protein Name: Biglycan
• Protein Family: Biglycan
• UniProt Gene Name: BGN
• UniProt Synonym Gene Names: SLRR1A

NCBI Description

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]

Uniprot Description

BGN: May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cell surface; cytoplasm; extracellular matrix; extracellular region; Golgi lumen; lysosomal lumen; transport vesicle

Molecular Function: protein kinase inhibitor activity

Biological Process: chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; cytokine and chemokine mediated signaling pathway; dermatan sulfate biosynthetic process; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity

Disease: Meester-loeys Syndrome; Spondyloepimetaphyseal Dysplasia, X-linked