Related Product Information for anti-Frk antibody
Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Product Categories/Family for anti-Frk antibody
References
Akerblom, B., et al. Mol. Cell. Endocrinol. 270 (1-2), 73-78 (2007): Nishimura, M., et al. DNA Res. 11(5):315-323(2004). Sharov, A.A., et al. PLoS Biol. 1 (3), E74 (2003): Cowen, M.S., et al. Alcohol. Clin. Exp. Res. 27(8):1213-1219(2003). Serfas, M.S., et al. Oncol. Res. 13 (6-10), 409-419 (2003).
Uniprot Description
FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.
Protein type: Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; Tumor suppressor; TK group; Src family
Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; nucleus
Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity; receptor binding
Biological Process: cell migration; innate immune response; cell differentiation; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
Product Notes
The Frk frk (Catalog #
AAA6300135) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Frk, CT (Frk, Bsk, Iyk, Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, FYN-related kinase, Intestine tyrosine kinase) (PE) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Frk can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the Frk frk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"Frk, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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