Goat anti-Human, Mouse Interleukin 17B Polyclonal Antibody | anti-IL17B antibody

Interleukin 17B (IL-17B, Interleukin-17B, Cytokine Zcyto7, Interleukin-20, IL-20, Neuronal Interleukin-17-related Factor, IL17B, IL20, NIRF, ZCYTO7, UNQ516/PRO1031) (APC)

Cat. Num. AAA627289

• Gene Names: IL17B; NIRF; IL-20; IL-17B; ZCYTO7; MGC138900; MGC138901
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Interleukin 17B; Polyclonal Antibody; Interleukin 17B (IL-17B; Interleukin-17B; Cytokine Zcyto7; Interleukin-20; IL-20; Neuronal Interleukin-17-related Factor; IL17B; IL20; NIRF; ZCYTO7; UNQ516/PRO1031) (APC); Anti -Interleukin 17B (IL-17B; anti-IL17B antibody

• Host: Goat
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IL-17B. Species Crossreactivity
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, trehalose. Reconstitute with sterile PBS.

• Applicable Applications for anti-IL17B antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 0.1ug/ml.
• Immunogen: E. coli-derived recombinant human IL-17B, Gln21-Phe180 (Accession# Q9UHF5)
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-IL17B antibody

The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have also been reported. The functions of IL-17 RC, D, and E are not known. Human IL-17B cDNA encodes a 180aa protein with a putative 20aa signal peptide. Human and mouse IL-17B share 88% aa sequence identity. Among IL-17 family members, IL-17B is most closely related to IL-17D, sharing 27% aa sequence homology. IL-17B is expressed highly in spinal cord, and at lower levels in brain, kidney, lung, small intestine, prostate, testes, pancreas, adrenal gland and trachea. Expression of IL-17B has also been detected in chondrocytes in articular cartilage. IL-17B binds the IL-17B receptor but not IL-17 R and exhibits bioactivities distinct from those of IL-17.

Product Categories/Family for anti-IL17B antibody

Antibodies; Abs to Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 7657228
• NCBI GeneID: 27190
• NCBI Accession #: NP_055258.1
• NCBI GenBank Nucleotide #: NM_014443.2
• UniProt Accession #: Q6IAG3; Q9UHF5
• Molecular Weight: 20,465 Da
• NCBI Official Full Name: interleukin-17B
• NCBI Official Synonym Full Names: interleukin 17B
• NCBI Official Symbol: IL17B
• NCBI Official Synonym Symbols: NIRF; IL-20; IL-17B; ZCYTO7; MGC138900; MGC138901
• NCBI Protein Information: interleukin-17B; interleukin 20; interleukin-20; cytokine Zcyto7; OTTHUMP00000160526; interleukin-17 beta; cytokine-like protein ZCYTO7; neuronal interleukin-17 related factor; neuronal interleukin-17-related factor
• UniProt Protein Name: IL17B protein
• Protein Family: Interleukin
• UniProt Gene Name: IL17B
• UniProt Entry Name: Q6IAG3_HUMAN

NCBI Description

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. [provided by RefSeq]

Uniprot Description

IL17B: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: cell-cell signaling; immune response; inflammatory response