Rabbit anti-Mouse, Rat GABA Receptor A, alpha 6 Polyclonal Antibody | anti-GABRA3 antibody

GABA Receptor A, alpha 6 (Gamma-aminobutyric Acid Receptor Type A alpha 6 Subunit, GABRA6)

Cat. Num. AAA626219

• Reactivity: Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: GABA Receptor A; alpha 6; Polyclonal Antibody; alpha 6 (Gamma-aminobutyric Acid Receptor Type A alpha 6 Subunit; GABRA6); Anti -GABA Receptor A; anti-GABRA3 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes GABA Receptor A, alpha 6. No significant homology with other GABA A receptor subtypes or other receptors. Species sequence homology
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as liquid in 100mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.

• Applicable Applications for anti-GABRA3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA, Western Blot.; Dilution: Western Blot: 1-10ug/ml using ECL.; ELISA: 0.5-1ug/ml. Coat with 1ug/ml Control Peptide.
• Immunogen: Synthetic peptide (13aa) near the N-terminus of ra GAA alpha 6 subunit (KLH coupled).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-GABRA3 antibody

GABA (gamma-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABAA, GABAC and GABAB receptors (GABABRs). A family of GABA-A receptors subtypes exists. They are generated by alternative splicing of alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pie, theta and rho1-3 to form a heteromeric (pentameric) protein complexes. Various GABA-A subunits show distinct patterns of temporal and spatial expression that may imply its tissue specific physiological role (1). GABA A (GAA) receptor proteins (450-627aa) are characterized by the presence of a cleavable signal peptide, a large extracellular N-terminus, 3 TM (transmembrane) domains, a large cytoplasmic domain followed by TM4 and C-terminal extracellular domain. The regions between TM3-4 and the large cytoplasmic loop are least conserved among various GAA subunits, which may confer subunit specific functionality. GAA genes are distributed as clusters throughout the human genome (chromosomes 4, 5, 15, and X; delta subunit on chromosome 1). GAA in the brain are the targets of many clinically important drugs.

Product Categories/Family for anti-GABRA3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4557603
• NCBI GeneID: 2556
• NCBI Accession #: NP_000799.1
• NCBI GenBank Nucleotide #: NM_000808.3
• UniProt Accession #: P34903; Q8TAF9
• Molecular Weight: 55,165 Da
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit alpha-3
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) A receptor, alpha 3
• NCBI Official Symbol: GABRA3
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit alpha-3; GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alpha 3
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit alpha-3
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRA3
• UniProt Entry Name: GBRA3_HUMAN

NCBI Description

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

GABRA3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.

Protein type: Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway