Mouse anti-Human LAMP3 Monoclonal Antibody | anti-LAMP3 antibody

LAMP3 (Lysosome-associated Membrane Glycoprotein 3, LAMP-3, Lysosomal-associated Membrane Protein 3, DC-lysosome-associated Membrane Glycoprotein, DC LAMP, Protein TSC403, CD208, DCLAMP, TSC403) (Biotin)

Cat. Num. AAA6243060

• Gene Names: LAMP3; LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: LAMP3; Monoclonal Antibody; LAMP3 (Lysosome-associated Membrane Glycoprotein 3; LAMP-3; Lysosomal-associated Membrane Protein 3; DC-lysosome-associated Membrane Glycoprotein; DC LAMP; Protein TSC403; CD208; DCLAMP; TSC403) (Biotin); anti-LAMP3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: 13A205
• Specificity: Recognizes human LAMP-3.
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-LAMP3 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Immunogen: Recombinant corresponding to human LAMP-3.
• Conjugate: Biotin
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry Analysis: Representative Lot Data. Paraffin-embedded colorectal adenocarcinoma (Fig. 1 & 2) tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of LAMP-3. Reactivity was detected using the IHC- Select® Detection Kit. Positive staining was observed in colorectal adenocarcinoma tissue.)

Western Blot (WB)

(Western Blotting Analysis: Representative Lot Data. MCF-7 cell lysate was probed with LAMP-3 (1ug/ml). Proteins were visualized using a Goat Mouse IgG secondary antibody conjugated to HRP and visualized using a chemiluminescence detection system. Arrow indicates LAMP-3 (~65kD).)

Product Categories/Family for anti-LAMP3 antibody

Antibodies; CD Markers

References

1. Nagelkerke, A., et al. (2011). Cancer. doi: 10.1002/cncr.25938 {Published ahead of print} 2. Grutzkau, A., et al. (2004). Cytometry A. 61(1): 62-68. 3. de Saint-Vis, B., et al. (1998). Immunity. 9(3):325-336.

NCBI and Uniprot Product Information

• NCBI GI #: 38455385
• NCBI GeneID: 27074
• NCBI Accession #: NP_055213
• NCBI GenBank Nucleotide #: NM_014398.3
• UniProt Accession #: Q9UQV4; O94781; Q8NEC8; D3DNS4
• Molecular Weight: 38.8kDa (362aa) 57-70KDa (SDS-PAGE under reducing conditions)
• NCBI Official Full Name: lysosome-associated membrane glycoprotein 3
• NCBI Official Synonym Full Names: lysosomal associated membrane protein 3
• NCBI Official Symbol: LAMP3
• NCBI Official Synonym Symbols: LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP
• NCBI Protein Information: lysosome-associated membrane glycoprotein 3
• UniProt Protein Name: Lysosome-associated membrane glycoprotein 3
• Protein Family: Lysosome-associated membrane glycoprotein
• UniProt Gene Name: LAMP3
• UniProt Synonym Gene Names: DCLAMP; TSC403; LAMP-3; Lysosomal-associated membrane protein 3; DC LAMP
• UniProt Entry Name: LAMP3_HUMAN

NCBI Description

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

Uniprot Description

LAMP3: Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. Belongs to the LAMP family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.3-q27

Cellular Component: lysosomal membrane; integral to membrane

Biological Process: cell proliferation; immune system process