Goat anti-Human STAG3 Polyclonal Antibody | anti-STAG3 antibody

STAG3 (Stromal antigen 3, SCC3 homolog 3, cohesin subunit SA-3, stromalin 3)

Cat. Num. AAA622632

• Gene Names: STAG3; STAG3
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: STAG3; Polyclonal Antibody; STAG3 (Stromal antigen 3; SCC3 homolog 3; cohesin subunit SA-3; stromalin 3); Anti -STAG3 (Stromal antigen 3; anti-STAG3 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human STAG3.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-STAG3 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: Peptide ELISA: 1:16,000.; Western Blot: Preliminary experiments gave bands at approx 170kD and 26kD in Human Testis lysates after 1ug/ml antibody staining. Optimal dilutions to be determined by the researcher.
• Immunogen: A synthetic peptide from the C-terminus of aa--KPNREDVSSSQEE.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-STAG3 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 6114601
• NCBI GeneID: 10734
• UniProt Accession #: Q9UJ98; Q8NDP3; A6H8Z1; D6W5U8
• Molecular Weight: 139,034 Da
• NCBI Official Full Name: stromal antigen 3, (STAG3)
• NCBI Official Synonym Full Names: stromal antigen 3
• NCBI Official Symbol: STAG3
• NCBI Official Synonym Symbols: STAG3
• NCBI Protein Information: cohesin subunit SA-3; stromalin 3; stromalin-3; SCC3 homolog 3; OTTHUMP00000207376; OTTHUMP00000207395; OTTHUMP00000207396
• UniProt Protein Name: Cohesin subunit SA-3
• Protein Family: STAG3-like protein
• UniProt Gene Name: STAG3
• UniProt Entry Name: STAG3_HUMAN

NCBI Description

The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]

Uniprot Description

STAG3: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular space; nucleolus; synaptonemal complex; nucleus; chromosome, pericentric region

Biological Process: synaptonemal complex assembly

Disease: Premature Ovarian Failure 8