Mouse anti-Human RBAK Monoclonal Antibody | anti-RBAK antibody
RBAK (RB-associated KRAB Zinc Finger Protein, RB-associated KRAB Repressor, hRBaK, Zinc Finger Protein 769, ZNF769) (HRP)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
Uniprot Description
RBAK: May repress E2F-dependent transcription. May promote AR- dependent transcription. Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: nucleus
Molecular Function: nucleic acid binding; zinc ion binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent