Rabbit anti-Human Interleukin 22R Polyclonal Antibody | anti-IL22RA1 antibody

Interleukin 22R, NT (IL-22R NT, CRF2-9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor)

Cat. Num. AAA614297

• Gene Names: IL22RA1; IL22R; CRF2-9; IL22R1
• Reactivity: Human
• Applications: Western Blot, Neutralization Assay
• Purity: Affinity Purified; Immunoaffinity purified IgG
• Synonyms: Interleukin 22R; Polyclonal Antibody; NT (IL-22R NT; CRF2-9; IL-TIF R1; IL-10 Related T Cell-derived Inducible Factor); Anti -Interleukin 22R; anti-IL22RA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human Interleukin-22R. An approximately 62kD band can be detected.
• Purity/Purification: Affinity Purified; Immunoaffinity purified IgG
• Form/Format: 100ug in 200ul of PBS, 0.02% sodium azide.

• Applicable Applications for anti-IL22RA1 antibody: Western Blot (WB), Neutralization
• Application Notes: Suitable for use in Western Blotting.; Dilution: 0.5-1ug/ml; Human HepG2 cell lysate can be used as positive control.
• Immunogen: Synthetic peptide (QSSNFENILTWDSGPE) corresponding to amino acids 31 to 46 of human IL-22R precursor (1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of IL-22R expression in human HepG2 cell lysate with anti-IL-22R (CT) at 1 ug /ml.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of MBS614297.)

Related Product Information for anti-IL22RA1 antibody

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1-3). The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently (5-7). IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

Product Categories/Family for anti-IL22RA1 antibody

Antibodies; Abs to Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 31317239
• NCBI GeneID: 58985
• NCBI Accession #: NP_067081.2
• NCBI GenBank Nucleotide #: NM_021258.3
• UniProt Accession #: Q8N6P7; Q9HB22; A8K839; B2R9Y9
• Molecular Weight: 63,077 Da
• NCBI Official Full Name: interleukin-22 receptor subunit alpha-1
• NCBI Official Synonym Full Names: interleukin 22 receptor, alpha 1
• NCBI Official Symbol: IL22RA1
• NCBI Official Synonym Symbols: IL22R; CRF2-9; IL22R1
• NCBI Protein Information: interleukin-22 receptor subunit alpha-1; IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; cytokine receptor family 2 member 9
• UniProt Protein Name: Interleukin-22 receptor subunit alpha-1
• Protein Family: Interleukin-22 receptor
• UniProt Gene Name: IL22RA1
• UniProt Synonym Gene Names: IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9
• UniProt Entry Name: I22R1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

Uniprot Description

IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon receptor activity; interleukin-20 binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium