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Western Blot (WB) (Western blot analysis of IL-22 Receptor expression in human HepG2 cell lysate with IL-22 Receptor antibody at 1 ug /ml.)

Rabbit IL-22 Polyclonal Antibody | anti-IL-22 antibody

IL-22 Receptor Antibody

Gene Names
IL22RA1; IL22R; CRF2-9; IL22R1
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
IL-22; Polyclonal Antibody; IL-22 Receptor Antibody; IL22R; anti-IL-22 antibody
Ordering
For Research Use Only!
Host
Rabbit
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
2795
Applicable Applications for anti-IL-22 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a synthetic peptide corresponding to amino acids 560 to 574 of human IL-22 receptor precursor.
Target Name
IL-22 Receptor
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of IL-22 Receptor expression in human HepG2 cell lysate with IL-22 Receptor antibody at 1 ug /ml.)

Western Blot (WB) (Western blot analysis of IL-22 Receptor expression in human HepG2 cell lysate with IL-22 Receptor antibody at 1 ug /ml.)
Related Product Information for anti-IL-22 antibody
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Product Categories/Family for anti-IL-22 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
63,077 Da
NCBI Official Full Name
Homo sapiens IL-22 receptor (IL22R) mRNA, complete cds
NCBI Official Synonym Full Names
interleukin 22 receptor, alpha 1
NCBI Official Symbol
IL22RA1
NCBI Official Synonym Symbols
IL22R; CRF2-9; IL22R1
NCBI Protein Information
interleukin-22 receptor subunit alpha-1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-1
UniProt Gene Name
IL22RA1
UniProt Synonym Gene Names
IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9
UniProt Entry Name
I22R1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

Uniprot Description

IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon receptor activity; interleukin-20 binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium

Research Articles on IL-22

Similar Products

Product Notes

The IL-22 il22ra1 (Catalog #AAA9409436) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IL-22 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the IL-22 il22ra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-22, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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