Rabbit anti-Mouse, Rat Opioid Receptor, kappa, Internal Polyclonal Antibody | anti-OPRK1 antibody

Opioid Receptor, kappa, Internal (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK)

Cat. Num. AAA612986

• Gene Names: OPRK1; KOR; OPRK
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by peptide affinity chromatography.
• Synonyms: Opioid Receptor; kappa; Internal; Polyclonal Antibody; Internal (OPRK1; kappa 1; Kappa-type Opioid Receptor; KOR; KOR-1; OPRK); Anti -Opioid Receptor; anti-OPRK1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse opioid receptor. Species Crossreactivity
• Purity/Purification: Affinity Purified; Purified by peptide affinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.3, 1mg/ml BSA (IgG, protease free), 0.05% sodium azide, 50% glycerol.

• Applicable Applications for anti-OPRK1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:1000
• Immunogen: Synthetic peptide derived from the internal region of the mouse k-opioid receptor.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-OPRK1 antibody

Opioid receptors are G-protein coupled receptors. Although the function of k-opioid receptors is unclear, recent evidence indicates that activation of the k-opioid receptor opposes a variety of mu-opioid receptor mediated actions throughout the brain and spinal cord. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.

Product Categories/Family for anti-OPRK1 antibody

Antibodies; Abs to Opioid Receptors; Agonists

NCBI and Uniprot Product Information

• NCBI GI #: 71533992
• NCBI GeneID: 4986
• UniProt Accession #: P41145; Q499G4; Q8IWP3
• Molecular Weight: 42,645 Da
• NCBI Official Full Name: Opioid receptor, kappa 1
• NCBI Official Synonym Full Names: opioid receptor, kappa 1
• NCBI Official Symbol: OPRK1
• NCBI Official Synonym Symbols: KOR; OPRK
• NCBI Protein Information: kappa-type opioid receptor; KOR-1; K-OR-1; OTTHUMP00000226313; OTTHUMP00000226316; kappa opioid receptor; Opiate receptor, kappa-1
• UniProt Protein Name: Kappa-type opioid receptor
• Protein Family: Kappa-type opioid receptor
• UniProt Gene Name: OPRK1
• UniProt Synonym Gene Names: OPRK
• UniProt Entry Name: OPRK_HUMAN

Uniprot Description

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: neuron projection; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; behavior; opioid receptor, adenylate cyclase inhibiting pathway; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of saliva secretion; sensory perception of pain; defense response to virus