Rabbit anti-Human Phosphodiesterase 6A Polyclonal Antibody | anti-PDE6A antibody

Phosphodiesterase 6A (PDE6A, CGPR-A, EC 3.1.4.35)

Cat. Num. AAA612508

• Gene Names: PDE6A; PDEA; RP43; CGPR-A
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Phosphodiesterase 6A; Polyclonal Antibody; Phosphodiesterase 6A (PDE6A; CGPR-A; EC 3.1.4.35); Anti -Phosphodiesterase 6A (PDE6A; anti-PDE6A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes Human Phosphodiesterase 6A (PDE6A). Species Crossreactivity: Human.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% sodium azide.

• Applicable Applications for anti-PDE6A antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry: 10ug/ml
• Immunogen: Synthetic peptide, KLH-conjugated. Epitope: N-terminal region of human
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(PDE6A / PDE6 Alpha was used in IHC to stain formalin-fixed, paraffin-embedded human eye, retina, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.)

Product Categories/Family for anti-PDE6A antibody

Antibodies; Abs to Enzymes; Phosphodiesterase

NCBI and Uniprot Product Information

• NCBI GI #: 119582161
• NCBI GeneID: 5145
• UniProt Accession #: P16499; Q0P638; O75316
• Molecular Weight: 99,547 Da
• NCBI Official Full Name: phosphodiesterase 6A, cGMP-specific, rod, alpha, isoform CRA_b
• NCBI Official Synonym Full Names: phosphodiesterase 6A, cGMP-specific, rod, alpha
• NCBI Official Symbol: PDE6A
• NCBI Official Synonym Symbols: PDEA; RP43; CGPR-A
• NCBI Protein Information: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; PDE V-B1; GMP-PDE alpha; OTTHUMP00000160522; cGMP phosphodiesterase alpha subunit; rod photoreceptor cGMP phosphodiesterase alpha subunit
• UniProt Protein Name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
• Protein Family: Rod cGMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6A
• UniProt Synonym Gene Names: PDEA
• UniProt Entry Name: PDE6A_HUMAN

NCBI Description

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq]

Uniprot Description

PDE6A: This protein participates in processes of transmission and amplification of the visual signal. Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43). RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the cyclic nucleotide phosphodiesterase family.

Protein type: Phosphodiesterase; EC 3.1.4.35

Chromosomal Location of Human Ortholog: 5q31.2-q34

Cellular Component: plasma membrane

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; cytosolic calcium ion homeostasis; visual perception; retina development in camera-type eye; GMP metabolic process

Disease: Retinitis Pigmentosa 43