Rabbit CCDC45 Polyclonal Antibody | anti-CCDC45 antibody

CCDC45 (D623) Polyclonal Antibody

Cat. Num. AAA3013913

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CCDC45; Polyclonal Antibody; CCDC45 (D623) Polyclonal Antibody; Centrosomal protein of 95 kDa; Cep95; Coiled-coil domain-containing protein 45; CEP95; CEP45; anti-CCDC45 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CCDC45 (D623) polyclonal antibody detects endogenous levels of CCDC45 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 821

• Applicable Applications for anti-CCDC45 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 593-653 of Human CCDC45.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CCDC45 (D623) polyclonal antibody at 1:500 dilutionLane1:C6 whole cell lysate (40ug) Lane2:CT26 whole cell lysate (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug) Lane5:A2780 whole cell lysate (30ug))

Related Product Information for anti-CCDC45 antibody

The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC45 (coiled-coil domain containing 45) is a 821 amino acid protein encoded by a gene that maps to human chromosome 17q23.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1, 200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

NCBI and Uniprot Product Information

• NCBI GI #: 19923899
• NCBI Accession #: NP_612372.1
• NCBI GenBank Nucleotide #: NP_612372.1
• UniProt Accession #: Q96GE4
• Molecular Weight: ~ 95kDa
• NCBI Official Full Name: centrosomal protein of 95 kDa isoform 1
• UniProt Protein Name: Centrosomal protein of 95 kDa
• UniProt Gene Name: CEP95
• UniProt Synonym Gene Names: CCDC45; CEP45
• UniProt Entry Name: CEP95_HUMAN

Uniprot Description

CCDC45: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: spindle pole; centrosome; cytoplasm