Mouse anti-Human ProCollagen Type I C-Terminal Propeptide Monoclonal Antibody | anti-PICP antibody

ProCollagen Type I C-Terminal Propeptide (PICP) (HRP)

Cat. Num. AAA6122079

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: ProCollagen Type I C-Terminal Propeptide; Monoclonal Antibody; ProCollagen Type I C-Terminal Propeptide (PICP) (HRP); anti-PICP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 6F177
• Specificity: Recognizes native human ProCollagen Type I Propeptide (PICP).
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4. Labeled with horseradish peroxidase (HRP).

• Applicable Applications for anti-PICP antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: PICP purified from second trimester amniotic fluid.
• Hybridoma: X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Related Product Information for anti-PICP antibody

Type I collagen is present in connective tissue and bone where it makes up about 90% of the organic matrix. Type I collagen is produced from type-I procollagen by the proteolytic cleavage of N- and C-telopeptides, which are released into the circulation. The propeptides can be measured in serum as markers of the production of trype-I collagen. Elevated values of these propeptides are found in serum from patients with various metabolic or malignant bone diseases. Procollagen type I C-terminal propeptide (PICP) has a molecular mass of ~100kD. Its normal concentration in serum depends on age and sex.

Product Categories/Family for anti-PICP antibody

Antibodies; Collagen

References

1. Hertel NT, et al., (1993) Serum concentrations of type I and III procollagen propeptides in healthy children and girls with central precocious puberty during treatment with gonadotropin-releasing hormone analog and cyproterone acetate. J Clin Endocrinol Metab 76:924-927. 2. Kjeldsen J, et al., (2001) Collagen metabolites in the peripheral and splanchnic circulation of patients with Crohn disease. Scand J Gastroenterol 36:1193-1197. 3. Orum O, et al., (1996) Procollagen type I N-terminal propeptide (PINP) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism. Bone 19:157-163.