Rabbit anti-Human MAP126 Protein Polyclonal Antibody | anti-Spag5 antibody
MAP126 Protein
Gene Names
Spag5; S17; MAP126; Deepest; Mastrin; AI874642; D11Bhm180e; Spag5
Reactivity
Human
Applications
Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
MAP126 Protein; Polyclonal Antibody; Anti -MAP126 Protein; anti-Spag5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Reacts with the human MAP126 protein.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide before the addition of 40% glycerol.
Applicable Applications for anti-Spag5 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 1:250-1:500
Dilution: Western Blot: 1:250-1:500
Immunogen
Human MAP126 protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Spag5 antibody
A novel gene product, hMAP126, interacts with p29 in the yeast two-hybrid assay. The subcellular distribution of hMAP126 was localized to the mitotic spindle and is phosphorylated by p34(cdc2) kinase. Human MAP126 is likely involved in the functional and dynamic regulation of mitotic spindles.
Product Categories/Family for anti-Spag5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
129,993 Da
NCBI Official Full Name
MAP126
NCBI Official Synonym Full Names
sperm associated antigen 5
NCBI Official Symbol
Spag5
NCBI Official Synonym Symbols
S17; MAP126; Deepest; Mastrin; AI874642; D11Bhm180e; Spag5
NCBI Protein Information
sperm-associated antigen 5; astrin; OTTMUSP00000000156; microtubule-associated protein; mitotic spindle-associated protein p126
UniProt Protein Name
Sperm-associated antigen 5
Protein Family
UniProt Gene Name
Spag5
UniProt Entry Name
SPAG5_MOUSE
Uniprot Description
SPAG5: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; kinetochore; microtubule; cytoskeleton; spindle microtubule; cell; cytoplasm; spindle; chromosome; nucleus; chromosome, pericentric region
Molecular Function: microtubule binding
Biological Process: mitosis; regulation of attachment of spindle microtubules to kinetochore; mitotic sister chromatid segregation; cell division; establishment of spindle orientation; cell cycle; spindle organization and biogenesis; chromosome segregation
Research Articles on Spag5
1. Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
2. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
2. cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
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Product Notes
The Spag5 spag5 (Catalog #AAA611364) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAP126 Protein reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MAP126 Protein can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1:250-1:500. Researchers should empirically determine the suitability of the Spag5 spag5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAP126 Protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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