Rabbit anti-Rat Vasopressin Receptor V1a Polyclonal Antibody | anti-Avpr1a antibody

Vasopressin Receptor V1a (AVR-V1a)

Cat. Num. AAA610982

• Gene Names: Avpr1a; V1a; AVPR; V1aR; MGC108538
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Vasopressin Receptor V1a; Polyclonal Antibody; Vasopressin Receptor V1a (AVR-V1a); Anti -Vasopressin Receptor V1a (AVR-V1a); anti-Avpr1a antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat Arginine Vasopressin Receptor V1a (AVR-V1a). The immunogen shows no significant sequence homology with human AVP-V1a or other receptor subtypes (AVR-V1b, AVR-V2 or AVR-V3).
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in 0.05% sodium azide.

• Applicable Applications for anti-Avpr1a antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and ELISA.; Dilution: Western Blot: 1:1000-1:5000 using ECL.; ELISA: 1:10,000-1:50,000 using 1ug/ml control peptide per well
• Immunogen: Synthetic peptide corresponding to18aa within the cytoplasmic domain of rat AVR-V1a, conjugated to KLH Species Sequence Homology: mouse, 55%
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Avpr1a antibody

Rat AVR-V1a receptor is a G-protein coupled membrane protein with seven transmembrane domains. N-terminus is predicted to be extracellular. Vasopressin (AVP, Arginine-8-Vasopressin), the antidiuretic hormone is cyclic nonapeptide involved in the homeostasis of body fluid osmolality, blood volume, vascular tone, and blood pressure. Specific actions of AVP include inhibition of diuresis, contraction of smooth muscle, stimulation of liver glycogenesis, and modulation of ACTH release from pituitary. AVP belongs to the family of vasoactive and mitogenic peptides involved in normal and pathological cell growth and differentiation. AVP exerts its action through binding to specific membrane receptors coupled to distinct second messengers. There are 3 types of AVP receptors: V1a, V1b, and V2 subtypes. The V2 receptor stimulates adenyl cyclase and protein Kinase A, V1 activate phospholipase A2.C, and D, resulting into production of IP3 and DAG, the mobilization of intracellular calcium, the influx of extracellular calcium, the activation of protein Kinase C, and protein phosphorylation.

Product Categories/Family for anti-Avpr1a antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 33149327
• NCBI GeneID: 25107
• NCBI Accession #: NP_444178.2
• NCBI GenBank Nucleotide #: NM_053019.2
• UniProt Accession #: P30560; Q5M8D1; Q62874; Q9QW18
• Molecular Weight: 47,655 Da
• NCBI Official Full Name: vasopressin V1a receptor
• NCBI Official Synonym Full Names: arginine vasopressin receptor 1A
• NCBI Official Symbol: Avpr1a
• NCBI Official Synonym Symbols: V1a; AVPR; V1aR; MGC108538
• NCBI Protein Information: vasopressin V1a receptor; antidiuretic hormone receptor 1a; arginine vasopressin receptor V1a; vascular/hepatic-type arginine vasopressin receptor
• UniProt Protein Name: Vasopressin V1a receptor
• Protein Family: Vasopressin V1a receptor
• UniProt Gene Name: Avpr1a
• UniProt Entry Name: V1AR_RAT

NCBI Description

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues. [provided by RefSeq]

Uniprot Description

AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; integral to membrane; plasma membrane; cytoplasmic vesicle

Molecular Function: peptide hormone binding; V1A vasopressin receptor binding; vasopressin receptor activity

Biological Process: positive regulation of glutamate secretion; positive regulation of cellular pH reduction; cellular response to water deprivation; positive regulation of systemic arterial blood pressure; positive regulation of glycogen catabolic process; response to organic substance; elevation of cytosolic calcium ion concentration; positive regulation of cell proliferation; response to corticosterone stimulus; positive regulation of prostaglandin biosynthetic process; penile erection; grooming behavior; response to inorganic substance; maternal behavior; calcium-mediated signaling; myotube differentiation; positive regulation of heart rate; social behavior; positive regulation of cell growth; cellular response to hormone stimulus; negative regulation of female receptivity; G-protein coupled receptor protein signaling pathway; telencephalon development; negative regulation of transmission of nerve impulse; regulation of systemic arterial blood pressure by vasopressin; regulation of adrenocorticotropin hormone secretion; positive regulation of vasoconstriction; sperm ejaculation; positive regulation of blood pressure