Mouse anti-Human, Mouse ErbB4 Monoclonal Antibody | anti-Erbb4 antibody

ErbB4 (c-erbB4, HER4)

Cat. Num. AAA603899

• Gene Names: Erbb4; Her4; c-erbB-4
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ErbB4; Monoclonal Antibody; ErbB4 (c-erbB4; HER4); Anti -ErbB4 (c-erbB4; anti-Erbb4 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 3F168
• Specificity: Recognizes human ErbB4. Species Crossreactivity: mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See E3451-40CX

• Applicable Applications for anti-Erbb4 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.
• Immunogen: Synthetic peptide corresponding to aa1249-1264, Cys-RSTLQHPDYLQEYST from the human c-erbB-4/HER-4 oncoprotein. MW of Antigen: 185kD Epitope: aa1249-1264 Cellular Localization: Cytoplasmic and cell membrane
• Cellular Localization: Cytoplasmic and cell membrane
• Positive Control: Breast carcinoma or skeletal muscle.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Erbb4 antibody

c-erbB-4 is the fourth member of class I receptor kinase family (ErbB). HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.

Product Categories/Family for anti-Erbb4 antibody

Antibodies; Abs to Oncoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 986917
• NCBI GeneID: 13869
• UniProt Accession #: O88459; Q61527
• Molecular Weight: 9,891 Da
• NCBI Official Full Name: erbB4
• NCBI Official Synonym Full Names: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
• NCBI Official Symbol: Erbb4
• NCBI Official Synonym Symbols: Her4; c-erbB-4
• NCBI Protein Information: receptor tyrosine-protein kinase erbB-4; OTTMUSP00000030425; OTTMUSP00000030426; OTTMUSP00000030427; avian erythroblastosis oncogene B 4; proto-oncogene-like protein c-ErbB-4
• UniProt Protein Name: EGF-like growth factor receptor ErbB4 extracellular domain
• Protein Family: Receptor tyrosine-protein kinase
• UniProt Gene Name: Erbb4
• UniProt Entry Name: O88459_MOUSE

Uniprot Description

HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; TK group; EGFR family

Cellular Component: membrane; mitochondrion; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; integral to membrane; caveola; nucleus; receptor complex; lipid raft

Molecular Function: transferase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding; protein kinase activity; epidermal growth factor receptor binding

Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; multicellular organismal development; heart development; signal transduction; embryonic pattern specification; olfactory bulb interneuron differentiation; protein amino acid phosphorylation; regulation of cell migration; negative regulation of cell proliferation; positive regulation of glucose import; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; mitochondrial fragmentation during apoptosis; phosphorylation; surfactant homeostasis; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of cell migration