Western Blot (WB)
(Western Blot detection against Immunogen (38.21kD).)
Mouse anti-Human PXDN Monoclonal Antibody | anti-PXDN antibody
PXDN (Peroxidasin Homolog, Melanoma-associated Antigen MG50, Vascular Peroxidase 1, p53-responsive Gene 2 Protein, KIAA0230, MG50, PRG2, VPO, VPO1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot detection against Immunogen (38.21kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (38.21kD).)
Testing Data
(Detection limit for recombinant GST tagged PXDN is 0.03ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged PXDN is 0.03ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM, Jul 2009]
Uniprot Description
PXDN: Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. Belongs to the peroxidase family. XPO subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide; Oxidoreductase; EC 1.11.1.7
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum
Molecular Function: peroxidase activity; metal ion binding; extracellular matrix structural constituent; heme binding; interleukin-1 receptor antagonist activity
Biological Process: extracellular matrix organization and biogenesis; hydrogen peroxide catabolic process; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; response to oxidative stress
Disease: Corneal Opacification With Other Ocular Anomalies
Research Articles on PXDN
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Product Notes
The PXDN pxdn (Catalog #AAA6011940) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PXDN (Peroxidasin Homolog, Melanoma-associated Antigen MG50, Vascular Peroxidase 1, p53-responsive Gene 2 Protein, KIAA0230, MG50, PRG2, VPO, VPO1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PXDN can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the PXDN pxdn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: STSAFSTRSD ASGTNDFREF VLEMQKTITD LRTQIKKLES RLSTTECVDA GGESHANNTK WKKDACTICE CKDGQVTCFV EACPPATCAV PVNIPGACCP VCLQKRAEEK *. It is sometimes possible for the material contained within the vial of "PXDN, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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