Rabbit anti-Human SERPINB9 Polyclonal Antibody | anti-SERPINB9 antibody

SERPINB9, ID (SERPINB9, PI9, Serpin B9, Cytoplasmic antiproteinase 3, Peptidase inhibitor 9)

Cat. Num. AAA6011365

• Gene Names: SERPINB9; PI9; CAP3; PI-9; CAP-3
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SERPINB9; Polyclonal Antibody; ID (SERPINB9; PI9; Serpin B9; Cytoplasmic antiproteinase 3; Peptidase inhibitor 9); Anti -SERPINB9; anti-SERPINB9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-SERPINB9 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: SERPINB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the Central region of human SERPINB9.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SERPINB9 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SERPINB9 antibody detected the SERPINB9 protein (arrow).)

Related Product Information for anti-SERPINB9 antibody

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995 [PubMed 8530382]).

Product Categories/Family for anti-SERPINB9 antibody

Antibodies; Abs to Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 4758906
• NCBI GeneID: 5272
• NCBI Accession #: NP_004146.1
• NCBI GenBank Nucleotide #: NM_004155.5
• UniProt Accession #: P50453; Q5TD03; B2RBW3
• Molecular Weight: 42,404 Da
• NCBI Official Full Name: serpin B9
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade B (ovalbumin), member 9
• NCBI Official Symbol: SERPINB9
• NCBI Official Synonym Symbols: PI9; CAP3; PI-9; CAP-3
• NCBI Protein Information: serpin B9; peptidase inhibitor 9; cytoplasmic antiproteinase 3; protease inhibitor 9 (ovalbumin type); serpin peptidase inhibitor, clade B, member 9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
• UniProt Protein Name: Serpin B9
• Protein Family: Serpin
• UniProt Gene Name: SERPINB9
• UniProt Synonym Gene Names: PI9; CAP-3; CAP3; PI-9
• UniProt Entry Name: SPB9_HUMAN

NCBI Description

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Uniprot Description

SERPINB9: Granzyme B inhibitor. Belongs to the serpin family. Ov-serpin subfamily.

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: extracellular space; membrane; cytoplasm; intracellular; nucleus; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; caspase inhibitor activity

Biological Process: mast cell mediated immunity; response to bacterium; immune response; negative regulation of caspase activity; negative regulation by symbiont of host apoptosis; protection from natural killer cell mediated cytotoxicity; negative regulation of apoptosis