Western Blot (WB)
(Western Blot analysis of ATP6V0B expression in transfected 293T cell line by ATP6V0B polyclonal antibody. Lane 1: ATP6V0B transfected lysate (21.4kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human ATP6V0B Polyclonal Antibody | anti-ATP6V0B antibody
ATP6V0B (V-type Proton ATPase 21 kDa Proteolipid Subunit, V-ATPase 21 kDa Proteolipid Subunit, Vacuolar Proton Pump 21 kDa Proteolipid Subunit, hATPL, ATP6F)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of ATP6V0B expression in transfected 293T cell line by ATP6V0B polyclonal antibody. Lane 1: ATP6V0B transfected lysate (21.4kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of ATP6V0B expression in transfected 293T cell line by ATP6V0B polyclonal antibody. Lane 1: ATP6V0B transfected lysate (21.4kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ATP6V0B: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase proteolipid subunit family.
Protein type: Transporter, ion channel; Transporter; Transporter, iron; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: phagocytic vesicle membrane; vacuolar membrane; integral to membrane; endosome membrane
Molecular Function: transporter activity; hydrogen ion transmembrane transporter activity
Biological Process: interaction with host; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport
Research Articles on ATP6V0B
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Product Notes
The ATP6V0B atp6v0b (Catalog #AAA6009393) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATP6V0B (V-type Proton ATPase 21 kDa Proteolipid Subunit, V-ATPase 21 kDa Proteolipid Subunit, Vacuolar Proton Pump 21 kDa Proteolipid Subunit, hATPL, ATP6F) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ATP6V0B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the ATP6V0B atp6v0b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR VKMGD. It is sometimes possible for the material contained within the vial of "ATP6V0B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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