Rabbit anti-Human UBP46 Polyclonal Antibody | anti-USP2 antibody

UBP46, CT (USP46, Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46)

Cat. Num. AAA6008653

• Gene Names: USP2; UBP41; UBP46; ubp52; ubp66
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: UBP46; Polyclonal Antibody; CT (USP46; Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46); Anti -UBP46; anti-USP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-USP2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the C-terminal region of human UBP46.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(UBP46 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the UBP46 antibody detected the UBP46 protein (arrow).)

Related Product Information for anti-USP2 antibody

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).

Product Categories/Family for anti-USP2 antibody

Antibodies; Abs to Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 45382531
• NCBI GeneID: 395766
• NCBI Accession #: NP_990257.1
• NCBI GenBank Nucleotide #: NM_204926.1
• UniProt Accession #: O57429
• Molecular Weight: 40,932 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 2
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 2
• NCBI Official Symbol: USP2
• NCBI Official Synonym Symbols: UBP41; UBP46; ubp52; ubp66
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin thiolesterase 2; family of cysteine protease; ubiquitin specific protease 2; ubiquitin specific protease 41; ubiquitin specific protease 46; ubiquitin specific protease 52; ubiquitin specific protease 66; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 2
• Protein Family: Protein
• UniProt Gene Name: USP2
• UniProt Synonym Gene Names: UBP41
• UniProt Entry Name: UBP2_CHICK

Uniprot Description

Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities

By similarity.

Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Cofactor: Binds 1 zinc ion

By similarity.

Subunit structure: Homooligomer

By similarity.

Subcellular location: Cytoplasm

By similarity. Cytoplasm › perinuclear region

By similarity.

Sequence similarities: Belongs to the peptidase C19 family. USP2 subfamily.