Structure
Thyrotropin-Releasing Hormone (TRH), Inhibitor | TRH, inhibitor
Thyrotropin-Releasing Hormone (TRH), Free Acid
Purity
98.00%
Synonyms
Thyrotropin-Releasing Hormone (TRH); Free Acid; TRH-OH; TRH; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Boiling Point
896.0+/-65.0 degree C (Predicted)
Formula
C16H21N5O5
SMILES
O=C1CCC(C(=O)NC(Cc2c[nH]cn2)C(=O)N2CCCC2C(=O)O)N1
CAS Number
24769-58-2
Target & IC50
Others
In Vitro
Thyrotropin-releasing-hormone (TRH) stimulated the release of newly synthesized GH and PRL, but not thyroid-stimulating hormone. In addition, TRH stimulated a dose-related increase in the release of newly synthesized GH and PRL at 10(-9) to 10(-7) M. Cyclo(His-Pro) stimulated the release of newly synthesized GH dose- dependently. TRH, cyclo(His-Pro), and hGHRH stimulated GH synthesis, while SRIF inhibited this at 10(-7) M. The release of newly synthesized PRL into culture medium was also stimulated by TRH and hGHRH, but inhibited by SRIF. PRL synthesis was not affected by TRH-OH and cyclo(His-Pro). Intracellular contents of GH and PRL in the pituitary did not change significantly. TRH plays an important role in both GH and PRL synthesis and release[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for TRH, inhibitor
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels.
References
Kagabu Y, Mishiba T, Okino T, et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites, Cyclo(His-Pro) and TRH-OH, on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common Carp,Cyprinus carpio[J]. General & Comparative Endocrinology, 1998, 111(3):395-403.
Kagabu Y, Mishiba T, Okino T, et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites, Cyclo(His-Pro) and TRH-OH, on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common Carp,Cyprinus carpio[J]. General & Comparative Endocrinology, 1998, 111(3):395-403.
Lopez-Barneo J, Castellano A, Toledo-Aral J. Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154.
Lopez-Barneo J, Castellano A, Toledo-Aral J. Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154.
Eleonore F, Richard W. The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-.
Eleonore F, Richard W. The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-.
Kagabu Y, Mishiba T, Okino T, et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites, Cyclo(His-Pro) and TRH-OH, on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common Carp,Cyprinus carpio[J]. General & Comparative Endocrinology, 1998, 111(3):395-403.
Lopez-Barneo J, Castellano A, Toledo-Aral J. Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154.
Lopez-Barneo J, Castellano A, Toledo-Aral J. Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154.
Eleonore F, Richard W. The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-.
Eleonore F, Richard W. The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-.
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Product Notes
The TRH (Catalog #AAA5758310) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Thyrotropin-Releasing Hormone (TRH), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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