Structure
NVP-BSK805, inhibitor
NVP-BSK805
Purity
98.8%
Synonyms
NVP-BSK805; BSK 805; NVP-BSK805 2HCl; inhibitor
Purity/Purification
98.8%
Form/Format
Powder
Formula
C27H28F2N6O
CAS
1092499-93-8
Smiles
Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1
Receptor (IC50)
JAK1: 31.63nM
JAK2: ~0.5nM
JAK3: 18.68nM
Tyk2: 10.76nM
JAK2 JH1: 0.48nM
FL JAK2 V617F: 0.56nM
FL JAK2 wt: 0.58nM
TYK2 JH1: 10.76nM
JAK3 JH1: 18.68nM
JAK1 JH1: 31.63nM
JAK2: ~0.5nM
JAK3: 18.68nM
Tyk2: 10.76nM
JAK2 JH1: 0.48nM
FL JAK2 V617F: 0.56nM
FL JAK2 wt: 0.58nM
TYK2 JH1: 10.76nM
JAK3 JH1: 18.68nM
JAK1 JH1: 31.63nM
Solubility
DMSO: 10mMEthanol: 15mg/mL (26.62mM)
Water: 3mg/mL (5.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Water: 3mg/mL (5.32mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for NVP-BSK805, inhibitor
NVP-BSK805 is an ATP-competitive JAK2 inhibitor.
Product Categories/Family for NVP-BSK805, inhibitor
References
1. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490 (4):1176-1182.
2. Rubert J, et al. BMC Cancer, 2011, Jan (19), 11-24.
3. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9 (7):1945-55.
2. Rubert J, et al. BMC Cancer, 2011, Jan (19), 11-24.
3. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9 (7):1945-55.
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Product Notes
The NVP-BSK805 (Catalog #AAA5751513) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NVP-BSK805, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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