Structure
JAK/HDAC-IN-1, inhibitor
JAK/HDAC-IN-1
Purity
98.00%
Synonyms
JAK/HDAC-IN-1; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 20.83mg/mL (46.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H21Cl2N7O2
SMILES
ClC1=CC=C(NC2=NC(NC3=CN(CCCCCC(NO)=O)N=C3)=NC=C2Cl)C=C1
CAS Number
2284621-75-4
Target & IC50
JAK2: ic50 4nM
JAK1: ic50 4.8nM
JAK3: ic50 7.4nM
Tyk2: ic50 49nM
HDAC: ic50 2nM
HDAC2: ic50 14nM
HDAC6: ic50 120nM
HDAC8: ic50 2470nM
JAK1: ic50 4.8nM
JAK3: ic50 7.4nM
Tyk2: ic50 49nM
HDAC: ic50 2nM
HDAC2: ic50 14nM
HDAC6: ic50 120nM
HDAC8: ic50 2470nM
In Vitro
JAK/HDAC-IN-1 shows IC50s of 4.8, 7.4, and 49nM for JAK1, JAK3, and TYK2, and 14, 120, 2470nM for HDAC2, HDAC6 and HDAC8, respectively[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for JAK/HDAC-IN-1, inhibitor
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines.
Product Categories/Family for JAK/HDAC-IN-1, inhibitor
References
Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the treatment,of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.
Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the treatment,of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.
Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the treatment,of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.
Similar Products
Product Notes
The JAK/HDAC-IN-1 (Catalog #AAA5755013) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JAK/HDAC-IN-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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