Rabbit anti-Rat, Mouse Thy-1/CD90 Polyclonal Antibody | anti-Thy-1/CD90 antibody
Rabbit anti-rat Thy-1/CD90
Gene Names
Thy1; CD7
Reactivity
Rat, Mouse
Applications
Immunocytochemistry, Immunohistochemistry
Synonyms
Thy-1/CD90; Polyclonal Antibody; Rabbit anti-rat Thy-1/CD90; anti-Thy-1/CD90 antibody
Host
Rabbit
Reactivity
Rat, Mouse
Clonality
Polyclonal
Specificity
Thy-1 antiserum is directed against rat thymocyte-1 antigen (Thy-1) and also reacts with mouse Thy-1.
Form/Format
Each vial contains 100ul polyclonal antiserum containing 0.02% sodium azide.
Sequence Length
161
Applicable Applications for anti-Thy-1/CD90 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin
Application Notes
Thy-1 is suitable for the detection of rat and mouse Thy-1 by immunohistochemical staining of frozen tissue sections. After drying, the sections can be either left unfixed or fixed with acetone at 4 degree C for 4 min or 95% ethanol at 4 degree C for 15 min or 4% formaldehyde in phosphate buffered saline pH 7.4 at 20 degree C for 15 min. Also isolated cells can be immunocytochemically stained by this antiserum. Recommended range 1:50 - 1:100.
Source Note
Thy-1 antibody is a rabbit polyclonal antiserum obtained from rabbits immunised with purified Thy-1 derived from rat brain.
Preparation and Storage
Store at 4 degree C, or in small aliquots at -20 degree C.
Related Product Information for anti-Thy-1/CD90 antibody
Thymocyte-1 antigen (Thy-1), also known as CD90, is a glycophosphatidylinositol (GPI)-anchored cell surface glycoprotein that is a member of the immunoglobulin superfamily. Expression of Thy-1, originally identified as a marker of thymocyte differentiation in mice, has been found to vary between species. In rats, unlike mice, Thy-1 is expressed on bone marrow cells but not on peripheral T-cells. In both mice and rats, Thy-1 is abundantly expressed on thymocytes and neuronal cells and to a lesser extent on fibroblasts, myofibroblasts, vascular endothelial cells, mammary glands and other non-lymphoid tissues. In many tissues the level of Thy-1 expression changes during cell differentiation.
The exact function of Thy-1 has not been fully determined but studies suggest that Thy-1 may be an important regulator of cell-cell and cell-matrix interactions due to its involvement in a range of biological processes including cell growth and differentiation, cell adhesion and migration, apoptotic signalling and tumour suppression.
The exact function of Thy-1 has not been fully determined but studies suggest that Thy-1 may be an important regulator of cell-cell and cell-matrix interactions due to its involvement in a range of biological processes including cell growth and differentiation, cell adhesion and migration, apoptotic signalling and tumour suppression.
Product Categories/Family for anti-Thy-1/CD90 antibody
References
1. Barclay AN, Letarte-Muirhead M, Williams AF. (1975) Purification of the Thy-1 molecule from rat brain. Biochem J. 151:699-706. 2. Letarte-Muirhead M, Barclay AN, Williams AF. (1975) Purification of the Thy-1 molecule, a major cell-surface glycoprotein of rat thymocytes. Biochem J. 151:685-97. 3. Barclay AN, Hydén H. (1978) Localization of the Thy-1 antigen in rat brain and spinal cord by immunofluorescence. J Neurochem. 31:1375-91. 4. Barclay AN. (1979) Localization of the Thy-1 antigen in the cerebellar cortex of rat brain by immunofluorescence during postnatal development. J Neurochem. 32:1249-57. 5. Barclay AN, Hydén H. (1979) Localization of the Thy-1 antigen by immunofluorescence on neurons isolated from rat brain. J Neurochem. 32:1583-86.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,172 Da
NCBI Official Full Name
thy-1 membrane glycoprotein preproprotein
NCBI Official Synonym Full Names
Thy-1 cell surface antigen
NCBI Official Symbol
Thy1
NCBI Official Synonym Symbols
CD7
NCBI Protein Information
thy-1 membrane glycoprotein
UniProt Protein Name
Thy-1 membrane glycoprotein
UniProt Gene Name
Thy1
UniProt Synonym Gene Names
Thy-1
UniProt Entry Name
THY1_RAT
NCBI Description
cell surface glycoprotein antigen [RGD, Feb 2006]
Uniprot Description
THY1: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Protein type: Membrane protein, GPI anchor; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: anchored to external side of plasma membrane; anchored to plasma membrane; apical plasma membrane; cell surface; cytosol; dendrite; endoplasmic reticulum; external side of plasma membrane; focal adhesion; growth cone; lipid raft; myelin sheath; plasma membrane
Molecular Function: enzyme binding; GTPase activator activity; integrin binding; protein binding; protein kinase binding
Biological Process: angiogenesis; cell-cell adhesion; cytoskeleton organization and biogenesis; focal adhesion formation; mast cell activation; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of fibroblast proliferation; negative regulation of protein kinase activity; negative regulation of T cell receptor signaling pathway; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of T cell activation; protein amino acid autophosphorylation; retinal cone cell development; T cell receptor signaling pathway
Research Articles on Thy-1/CD90
Similar Products
Product Notes
The Thy-1/CD90 thy1 (Catalog #AAA573773) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-rat Thy-1/CD90 reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Thy-1/CD90 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin. Thy-1 is suitable for the detection of rat and mouse Thy-1 by immunohistochemical staining of frozen tissue sections. After drying, the sections can be either left unfixed or fixed with acetone at 4 degree C for 4 min or 95% ethanol at 4 degree C for 15 min or 4% formaldehyde in phosphate buffered saline pH 7.4 at 20 degree C for 15 min. Also isolated cells can be immunocytochemically stained by this antiserum. Recommended range 1:50 - 1:100. Researchers should empirically determine the suitability of the Thy-1/CD90 thy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thy-1/CD90, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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