Immunohistochemistry (IHC)
(IHC Analysis: Human placenta tissue stained with TAK1, pAb at 10µg/ml.)
Rabbit TAK1 Polyclonal Antibody | anti-TGF- beta -activated kinase-1 antibody
TAK1 polyclonal antibody
Suggested dilutions/conditions may not be available for all applications.
Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(IHC Analysis: Human placenta tissue stained with TAK1, pAb at 10µg/ml.)
Immunohistochemistry (IHC)
(IHC Analysis: Human placenta tissue stained with TAK1, pAb at 10µg/ml.)
NCBI and Uniprot Product Information
Uniprot Description
TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.
Protein type: Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; MLK family; TAK1 subfamily
Cellular Component: cytoplasm; intracellular; membrane; plasma membrane
Molecular Function: ATP binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: activation of MAPKK activity; angiogenesis; apoptosis; I-kappaB phosphorylation; MAPKKK cascade; neural tube formation; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway
Research Articles on TGF- beta -activated kinase-1
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Product Notes
The TGF- beta -activated kinase-1 map3k7 (Catalog #AAA565202) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TAK1 polyclonal antibody reacts with Human, Mouse, Rat, Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's TAK1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) (PS), Western Blot (WB). Western Blot (1ug/ml, colorimetric) Suggested dilutions/conditions may not be available for all applications. Researchers should empirically determine the suitability of the TGF- beta -activated kinase-1 map3k7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TAK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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