Rabbit anti-Human NYX Polyclonal Antibody | anti-NYX antibody

NYX, NT (NYX, CLRP, Nyctalopin) (Biotin)

Cat. Num. AAA6327449

• Gene Names: NYX; CLRP; NBM1; CSNB1; CSNB4; CSNB1A
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NYX; Polyclonal Antibody; NT (NYX; CLRP; Nyctalopin) (Biotin); Nyctalopin; anti-NYX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-NYX antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: NYX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59~89 amino acids from the N-terminal region of human NYX.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of NYX Antibody (N-term) in HL-60 cell line lysates (35ug/lane). NYX (arrow) was detected using the purified Pab.)

Related Product Information for anti-NYX antibody

The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq].

Product Categories/Family for anti-NYX antibody

Antibodies; Proteins

References

Leroy, B.P., et al. Br J Ophthalmol 93(5):692-696(2009). Zhang, Q., et al. Mol. Vis. 13, 330-336 (2007). Morgans, C.W., et al. Eur. J. Neurosci. 23(5):1163-1171(2006). Xiao, X., et al. J. Hum. Genet. 51(7):634-640(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 12007646
• NCBI GeneID: 60506
• NCBI Accession #: NP_072089
• NCBI GenBank Nucleotide #: NM_022567.2
• UniProt Accession #: Q9GZU5; Q2M1S4; Q5H983; Q9H4J0; D3DWC0
• Molecular Weight: 52,000 Da
• NCBI Official Full Name: nyctalopin
• NCBI Official Synonym Full Names: nyctalopin
• NCBI Official Symbol: NYX
• NCBI Official Synonym Symbols: CLRP; NBM1; CSNB1; CSNB4; CSNB1A
• NCBI Protein Information: nyctalopin
• UniProt Protein Name: Nyctalopin
• Protein Family: Nyctalopin
• UniProt Gene Name: NYX
• UniProt Synonym Gene Names: CLRP

NCBI Description

The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]

Uniprot Description

NYX: Defects in NYX are the cause of congenital stationary night blindness type 1A (CSNB1A); also called X- linked congenital stationary night blindness (XLCSNB). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNB1A is characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: cytoplasm; intracellular; proteinaceous extracellular matrix

Molecular Function: protein kinase inhibitor activity

Biological Process: cytokine-mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; visual perception

Disease: Night Blindness, Congenital Stationary, Type 1a