MDC (CCL22) Recombinant Protein | CCL22 recombinant protein
Mouse MDC (CCL22) Recombinant
Purity
>97%, as determined by SDS-PAGE and HPLC
Synonyms
MDC (CCL22); Mouse MDC (CCL22) Recombinant; Mouse MDC Recombinant; ccl22; mdc; ccl-22; SCYA22; CCL22 recombinant protein
Host
E Coli
Purity/Purification
>97%, as determined by SDS-PAGE and HPLC
Sequence Length
92
Domain
IL8
Host Note
Optimized DNA sequence encoding Mouse MDC (CCL22) mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Native Mouse MDC/CCL22 has a calculated molecular mass of approximately 8 kDa.
Recombinant MDC is a disulfide-linked homodimeric protein consisting of 67 amino acid residue subunits, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Recombinant MDC is a disulfide-linked homodimeric protein consisting of 67 amino acid residue subunits, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Preparation and Storage
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months.
Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Related Product Information for CCL22 recombinant protein
CCL22 (monocyte-derived chemokine) was described initially as a constitutively produced, thymus-specific chemokine, implicated in the recruitment of T cells. One of the functions of CCL22 originally described was induction of migration of CCR4+ Th2 cells, but it has additionally been shown to regulate migration of Tregs. CCL22 has been implicated in a number of diseases, including allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Similarly, a presumed role for CCR4+ cells has been suggested for endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes
Product Categories/Family for CCL22 recombinant protein
References
• lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: cfh, cd209, Eotaxin-3, and mhc2ta .J Rheumatol, Aug 2009; 36: 1590 - 1595.
• Eotaxin-3 is involved in churg–strauss syndrome – a serum marker closely correlating with disease activity .Rheumatology, Jun 2008; 47: 804 - 808.
• dsrna enhances Eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells .Eur. Respir. J., Nov 2005; 26: 795 - 803.
• chronic aeroallergen during infancy enhances Eotaxin-3 expression in airway epithelium and nerves .Am. J. Respir. Cell Mol. Biol., Jul 2005; 33: 1 - 8.
• Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions .Chest, Jun 2005; 127: 2094 - 2100.
• Eotaxin-3 is involved in churg–strauss syndrome – a serum marker closely correlating with disease activity .Rheumatology, Jun 2008; 47: 804 - 808.
• dsrna enhances Eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells .Eur. Respir. J., Nov 2005; 26: 795 - 803.
• chronic aeroallergen during infancy enhances Eotaxin-3 expression in airway epithelium and nerves .Am. J. Respir. Cell Mol. Biol., Jul 2005; 33: 1 - 8.
• Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions .Chest, Jun 2005; 127: 2094 - 2100.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
10,302 Da
NCBI Official Full Name
C-C motif chemokine 22
UniProt Protein Name
C-C motif chemokine 22
Protein Family
UniProt Gene Name
Ccl22
UniProt Synonym Gene Names
Abcd1; Scya22
UniProt Entry Name
CCL22_MOUSE
Uniprot Description
CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine activity; cytokine activity
Biological Process: immune response; chemotaxis; inflammatory response
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Product Notes
The CCL22 ccl22 (Catalog #AAA553251) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MDC (CCL22), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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