Ephrin Receptor B1 Positive Control | Ephb1 positive control
Eprhin Receptor B1 Positive Control
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
NCBI and Uniprot Product Information
Uniprot Description
EphB1: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known.
Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Eph family
Cellular Component: axon; cytoplasm; early endosome membrane; filopodium tip; integral to plasma membrane; lipid raft; membrane
Molecular Function: axon guidance receptor activity; protein complex binding; protein-tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process: angiogenesis; axon guidance; camera-type eye morphogenesis; cell-substrate adhesion; central nervous system projection neuron axonogenesis; cranial nerve development; ephrin receptor signaling pathway; formation of immunological synapse; optic nerve morphogenesis; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; regulation of JNK cascade; retinal ganglion cell axon guidance
Research Articles on Ephb1
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Product Notes
The Ephb1 ephb1 (Catalog #AAA542745) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Ephrin Receptor B1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:750. Researchers should empirically determine the suitability of the Ephb1 ephb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ephrin Receptor B1, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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