Rabbit THAP1 Polyclonal Antibody | anti-THAP1 antibody
THAP1 Antibody BIOTIN
Reactivity
HumanPredicted: Mouse, Rat
Applications
ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Purity
Immobilized antigen affinity chromatography
Synonyms
THAP1; Polyclonal Antibody; THAP1 Antibody BIOTIN; BIOTIN-Conjugated THAP domain-containing protein 1 Antibody; Nuclear proapoptotic factor antibody; THAP 1 antibody; THAP domain containing apoptosis associated protein 1 antibody; THAP domain containing protein 1 antibody; THAP domain protein 1 antibody; anti-THAP1 antibody
Host
Rabbit
Reactivity
Human
Predicted: Mouse, Rat
Predicted: Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5-1.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
213
Applicable Applications for anti-THAP1 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
ELISA: 1:10,000
ICC: 1:50-1:150
IHC: 1:50-1:150
IP: 1:200
WB: 1:500
ICC: 1:50-1:150
IHC: 1:50-1:150
IP: 1:200
WB: 1:500
Immunogen
Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1.
Conjugation
BIOTIN
Molecular Function
Identical protein binding; Sequence-specific DNA binding; Zinc ion binding
Subcellular Location
Nucleus; Nucleoplasm; PML body
Preparation and Storage
Store at -20 degree C for long term storage.
Related Product Information for anti-THAP1 antibody
Overview: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Structure: Belongs to the THAP1 family.
Expression: Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
Structure: Belongs to the THAP1 family.
Expression: Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
NCBI and Uniprot Product Information
Uniprot Description
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
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Product Notes
The THAP1 thap1 (Catalog #AAA5400826) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The THAP1 Antibody BIOTIN reacts with Human Predicted: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's THAP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Immunocytochemistry (ICC). ELISA: 1:10,000 ICC: 1:50-1:150 IHC: 1:50-1:150 IP: 1:200 WB: 1:500. Researchers should empirically determine the suitability of the THAP1 thap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "THAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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