Thyroid Peroxidase Native Protein | TPO native protein

Thyroid Peroxidase protein

Cat. Num. AAA537891

• Gene Names: TPO; MSA; TPX; TDH2A
• Applications: User optimized
• Purity: > 95% by SDS-PAGE analysis
• Synonyms: Thyroid Peroxidase; Thyroid Peroxidase protein; TPO protein; MSA protein; TPX protein; TPO native protein

• Host: Human
• Purity/Purification: > 95% by SDS-PAGE analysis
• Form/Format: Lyophilized from 20mM Tris, 50mM KCl, 0.1mM KI, pH 7.5 with no preservatives added. Reconstitute with 0.1ml of distilled water, aliquot and freeze at -20 degree C or lower.
• Concentration: 100ug/vial, lyophilized (varies by lot)

• Applicable Applications for TPO native protein: User optimized
• Source: Human thyroid glands
• Protein Type: Native
• Grade: Highly Pure
• Contaminants: None detected by SDS-PAGE
• Biohazard: Tissue extract tested by EIA and found to be negative for HBsAg, anti-HIV 1/2 and anti-HCV.
• Additional Remarks: Suitable foruse in immunoassays as solid phase antigen.
• Preparation and Storage: Ships on blue ice. Upon receipt store at -20 degree C while lyophilized. Once reconstituted, aliquot and store at -20°C or lower. Avoid multiple freeze thaw cycles.

Related Product Information for TPO native protein

Thyroid peroxidase or thyroperoxidase (TPO) is an enzyme expressed mainly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene.

Product Categories/Family for TPO native protein

Proteases; Inhibitors; & Enzymes; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 5705932
• NCBI GeneID: 7173
• NCBI Official Full Name: thyroid peroxidase, partial
• NCBI Official Synonym Full Names: thyroid peroxidase
• NCBI Official Symbol: TPO
• NCBI Official Synonym Symbols: MSA; TPX; TDH2A
• NCBI Protein Information: thyroid peroxidase
• UniProt Protein Name: Thyroid peroxidase
• Protein Family: Thyroid peroxidase
• UniProt Gene Name: TPO
• UniProt Synonym Gene Names: TPO
• UniProt Entry Name: PERT_HUMAN

NCBI Description

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Uniprot Description

TPO: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A). A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Belongs to the peroxidase family. XPO subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 1.11.1.8; Mitochondrial; Amino Acid Metabolism - tyrosine; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; plasma membrane

Molecular Function: peroxidase activity; heme binding; iodide peroxidase activity; calcium ion binding

Biological Process: embryonic hemopoiesis; hydrogen peroxide catabolic process; thyroid hormone generation; hormone biosynthetic process; response to oxidative stress

Disease: Thyroid Dyshormonogenesis 2a