Pulmonary surfactant-associated protein D ELISA Kit | SFTPD elisa kit

Human SP-D PicoKine ELISA Kit

Cat. Num. AAA177529

• Gene Names: SFTPD; SP-D; PSP-D; SFTP4; COLEC7
• Reactivity: Human. There is no detectable cross-reactivity with other relevant proteins.
• Synonyms: Pulmonary surfactant-associated protein D; Human SP-D PicoKine ELISA Kit; COLEC 7; COLEC7; Collectin-7; Collectin7; Lung surfactant protein D; PSP D; PSP-D; PSP-D Surfactant protein D; PSPD; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein D; Pulmonary surfactant associated protein PSP-D; SFTP 4; SFTP4; SFTPD; SFTPD_HUMAN; SP D; SP-D; Surfactant associated protein pulmonary 4; Surfactant pulmonary associated protein D; surfactant protein D; SFTPD elisa kit

• Reactivity: Human. There is no detectable cross-reactivity with other relevant proteins.
• Sequence Length: 375

• Samples: Cell culture supernates, serum and plasma (heparin, EDTA)
• Assay Type: Sandwich
• Sensitivity: <20pg/ml
• Immunogen: NSO, A21-F375
• Intra-Assay Precision: Sample 1: n=16; Mean(ng/ml): 6.32; Standard deviation: 0.537; CV(%): 8.5 Sample 2: n=16; Mean(ng/ml): 14.3; Standard deviation: 0.729; CV(%): 5.1 Sample 3: n=16; Mean(ng/ml): 25.4; Standard deviation: 1.7; CV(%): 6.7
• Inter-Assay Precision: Sample 1: n=24; Mean(ng/ml): 5.76; Standard deviation: 0.513; CV(%): 8.9 Sample 2: n=24; Mean(ng/ml): 13.5; Standard deviation: 1.24; CV(%): 9.2 Sample 3: n=24; Mean(ng/ml): 24.7; Standard deviation: 2; CV(%): 8.1
• Assay Range: 625pg/ml-40,000pg/ml
• Preparation and Storage: Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

Typical Testing Data/Standard Curve (for reference only)

(Human SP-D PicoKine ELISA Kit standard curve )

Related Product Information for SFTPD elisa kit

Description: Sandwich ELISA kit of Quantitative Detection for Human SP-D
Background: Surfactant, pulmonary-associated protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene. By fluorescence in situ hybridization, the SP-D gene was localized in 10q22.2-q23.1. On the basis of homology with other collectins, potential functions for SP-D include roles in innate immunity and surfactant metabolism, SP-D is produced in the bronchiolar and terminal epithelium of human fetal lung from about 21 weeks of gestation. What's more, SP-A and SP-D act as dual-function surveillance molecules that reverse orientation and function and become initiators of host-defense reactions.

NCBI and Uniprot Product Information

• NCBI GI #: 61699226
• NCBI GeneID: 6441
• NCBI Accession #: NP_003010.4
• NCBI GenBank Nucleotide #: NM_003019.4
• UniProt Accession #: P35247; Q5T0M3; Q6FH08; Q86YK9; Q8TCD8; Q9UCJ2; Q9UCJ3
• Molecular Weight: 37,728 Da
• NCBI Official Full Name: pulmonary surfactant-associated protein D
• NCBI Official Synonym Full Names: surfactant protein D
• NCBI Official Symbol: SFTPD
• NCBI Official Synonym Symbols: SP-D; PSP-D; SFTP4; COLEC7
• NCBI Protein Information: pulmonary surfactant-associated protein D; collectin 7; collectin-7; lung surfactant protein D; pulmonary surfactant apoprotein; surfactant, pulmonary-associated protein D; surfactant-associated protein, pulmonary 4
• UniProt Protein Name: Pulmonary surfactant-associated protein D
• Protein Family: Pulmonary surfactant-associated protein
• UniProt Gene Name: SFTPD
• UniProt Synonym Gene Names: COLEC7; PSPD; SFTP4; PSP-D; SP-D
• UniProt Entry Name: SFTPD_HUMAN

NCBI Description

The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]

Uniprot Description

SFTPD: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Belongs to the SFTPD family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.2-q23.1

Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; endocytic vesicle; lysosome; extracellular region

Molecular Function: protein binding; carbohydrate binding

Biological Process: receptor-mediated endocytosis; negative regulation of T cell proliferation; positive regulation of phagocytosis; negative regulation of interleukin-2 biosynthetic process; defense response to bacterium; innate immune response; respiratory gaseous exchange; surfactant homeostasis; alveolus development; macrophage chemotaxis; regulation of cytokine production